Genotypic Characterisation and Antimicrobial Resistance of Extended-Spectrum β-Lactamase-Producing in Humans, Animals, and the Environment from Lusaka, Zambia: Public Health Implications and One Health Surveillance.

Background: Extended-spectrum β-lactamases (ESBL) in are a serious concern due to their role in developing multidrug resistance (MDR) and difficult-to-treat infections.

Objective: This study aimed to identify ESBL-carrying strains from both clinical and environmental sources in Lusaka District, Zambia.

Methods: This cross-sectional study included 58 ESBL-producing strains from hospital inpatients, outpatients, and non-hospital environments.

Antimicrobial resistance patterns of bacterial pathogens their distribution in university teaching hospitals in Zambia.

To determine the antimicrobial resistance patterns of bacterial pathogens from urine, blood and wound infections and their distribution by age, sex and location. A total of 49,168 samples were collected, processed and analyzed. Multidrug resistance was observed in almost all bacterial pathogens in blood urine and wound swabs.