Publications by authors named "Benjamin Benoit"
Conserved MHC gene orthologs genetically map to the turkey MHC- B.
Cytogenet Genome Res
February 2015
The avian MHC-associated gene set includes orthologs to genes found throughout the human major histocompatibility complex (MHC), including some loci of the evolutionarily conserved class III region. In the turkey and other Galliformes, genes linked to the MHC have been identified because they are closely associated with class I or class II genes. This study was designed to evaluate additional class III genes for linkage to the avian MHC to further determine conservation of these loci in birds.
View Article and Find Full Text PDFArticle Synopsis
- The turkey's major histocompatibility complex (MHC) is divided into two regions, MHC-B and MHC-Y, with this study focusing on the largely unexplored MHC-Y, identifying 14 predicted genes, including new class I- and class IIB-like loci.
- High-resolution fluorescence in situ hybridization revealed structural rearrangements in the turkey's MHC chromosome compared to the chicken's, indicating evolutionary changes like neocentromere formation or chromosome shifts.
- Comparative sequencing of commercial turkeys identified 68 genetic variations that correspond to nine distinct MHC-Y haplotypes, with all new gene loci expressing in the spleen, and some displaying differential expression across individuals.