Publications by authors named "Benito Gonzalez"
Background: Significant tricuspid regurgitation (TR) is associated with increased morbidity and mortality. The development of transcatheter valve repair therapies has opened a wide range of opportunities for treatment of patients with high surgical risk. Real-world data might improve patient selection and outcome.
View Article and Find Full Text PDFAims: To evaluate the association between transcatheter edge-to-edge repair (TEER) and outcomes in patients with significant mitral regurgitation (MR) following acute myocardial infarction (MI), focusing on the aetiology of acute post-MI MR in high-risk surgical patients.
Methods And Results: The International Registry of MitraClip in Acute Mitral Regurgitation following Acute Myocardial Infarction (IREMMI) includes 187 patients with severe MR post-MI managed with TEER. Of these, 176 were included in the analysis, 23 (13%) patients had acute papillary muscle rupture (PMR) and 153 (87%) acute secondary MR.
Background: Procedural success following tricuspid transcatheter edge-to-edge repair (TEER) has been defined variably over time; however, the consequences of achieving a tricuspid regurgitation (TR) grade of 0/1+ are still unclear.
Objectives: This study aimed to assess the predictors and prognostic impact of achieving TR 0/1+ after TEER and its role in clinical events.
Methods: This multicenter registry included patients undergoing tricuspid TEER in 15 Spanish centers from June 2020 and May 2023.
Article Synopsis
- Patients with a heart condition called atrial fibrillation (AF) who have strokes can still be at very high risk of having more strokes, even when taking medication to prevent them.
- Left atrial appendage occlusion (LAAO) is a special procedure aimed at helping these patients avoid future strokes.
- A study compared two groups – one that had LAAO and one that only continued their usual medication – and found that there was still a risk of strokes in both groups over a two-year period.
Article Synopsis
- Risk scores like MitraScore and COAPT help identify patients with mitral regurgitation (MR) who are at risk of adverse events but may still benefit from transcatheter edge-to-edge repair (TEER).
- The study validated MitraScore in the COAPT trial with 614 patients and the COAPT risk score in the MIVNUT registry with 1007 patients, both focusing on predicting all-cause mortality over approximately 2 years.
- Results indicated that both scores had fair to good predictive accuracy for mortality, with higher effectiveness seen in TEER patients, confirming the benefits of combining TEER with guideline-directed medical therapy (GDMT) across different risk levels.
Article Synopsis
- Patients with cardiogenic shock (CS) and mitral regurgitation (MR) face high surgical risks, but the study investigates the effectiveness of transcatheter edge-to-edge therapy (TEER) combined with mechanical circulatory support (MCS) for these patients.
- The MITRA-ASSIST study looked at 24 patients with CS and MR treated with TEER and MCS across nine Spanish centers, revealing a procedural success rate of 95.8% and 87.5% in-hospital survival.
- At 12 months, 25% of patients died, and 33.3% experienced either death or hospitalization for heart failure, suggesting that TEER combined with MCS could be a viable treatment
Article Synopsis
- Patients who underwent left atrial appendage occlusion (LAAO) have an increased risk of bleeding and thromboembolic events, leading researchers to investigate the role of hematological markers in predicting these risks.
- Data from 1,315 patients revealed that while the platelet count was somewhat associated with thromboembolic events, none of the hematological markers were linked to major bleeding events.
- Key factors influencing thromboembolism included age and previous thromboembolic history, while major bleeding risks were tied to prior events, renal disease, and dual antiplatelet therapy upon discharge.
The success of conservation programs for the taruka ( d'Orbigny), an endemic and endangered deer, depends on many factors, highlighting anthropogenic and ecological effects. Among the latter, how this herbivore interacts with forage resources is important. The objective of the study was to describe the main attributes of the diet of this deer in rangelands adjacent to agricultural areas of the foothills of the Tarapacá Region, Chile.
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- The study evaluated the effectiveness of the Vasopressor test (VPT) in patients with functional mitral regurgitation (MR) and left ventricular dysfunction undergoing transcatheter edge-to-edge repair (TEER).* -
- Out of 1115 patients, those who underwent VPT had higher rates of significant MR and greater overall mortality at one year compared to those who did not undergo the test, indicating a potentially higher risk profile.* -
- Despite the increased mortality rates in the VPT group, other key outcomes like heart failure readmissions and cardiovascular mortality showed no significant differences, suggesting VPT can aid in managing high-risk patients without worsening long-term outcomes.*
Article Synopsis
- Left atrial appendage occlusion (LAAO) is a treatment for patients with atrial fibrillation (AF) who can't use oral anticoagulation therapy (OAT) and those who face recurring thrombotic events despite OAT.
- This study compared the efficacy of LAAO in patients experiencing thrombotic events while on OAT against those who had contraindications for OAT, using data from a large registry and propensity score matching for accuracy.
- Results showed no significant difference in ischemic stroke rates between the two groups, but the LAAO patients on OAT had a higher thromboembolic risk but lower bleeding risk, suggesting LAAO is a viable option for these patients.
The increased availability of quality genomic data has greatly improved the scope and resolution of our understanding of the recent evolutionary history of wild species adapted to extreme environments and their susceptibility to anthropogenic impacts. The guanaco (Lama guanicoe), the largest wild ungulate in South America, is a good example. The guanaco is well adapted to a wide range of habitats, including the Sechura Desert, the high Andes Mountains to the north, and the extreme temperatures and conditions of Navarino Island to the south.
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- Malnutrition significantly impacts the prognosis of patients with secondary mitral regurgitation (SMR), with high rates of moderate to severe malnutrition detected among these patients undergoing transcatheter edge-to-edge repair (TEER).
- A study involving 658 patients revealed that moderate-severe malnutrition was linked to a higher risk of all-cause mortality and hospitalization due to heart failure, demonstrating its harmful effects on clinical outcomes.
- The findings suggest that nutritional status should be prioritized in the management and treatment of patients with SMR, as it remains an independent predictor of poor prognosis regardless of other factors.
Article Synopsis
- This study investigates device-related thrombus (DRT) occurrences after left atrial appendage closure (LAAC), focusing on how often it persists or recurs.
- It found that about 29% of DRT cases persist, with being female and having a larger initial thrombus size being significant predictors.
- Unfavorable DRT evolution is linked to a higher rate of thromboembolic events, emphasizing the importance of monitoring thrombus size post-LAAC.
Vine shoots (VS) and waste eucalyptus paperboard (EP) have been used as cellulose sources (in the form of cellulose nanocrystals -CNCs- and cellulosic fibers respectively) for developing cellulose-based aerogels. Two different parameters including cellulose concentration (0.5 % and 2 % w/v) and freezing temperatures (-20 °C and -80 °C) were tested to evaluate differences in the porosity of the aerogels via Brunauer-Emmett-Teller (BET) and thermal conductivity analyses.
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- This study investigates the use of myocardial strain (LVGLS) as a prognostic tool for selecting candidates for mitral transcatheter edge-to-edge valve repair in patients with severely reduced left ventricular ejection fraction (LVEF ≤40%).
- A total of 172 patients were examined, and results showed high procedural success (96.5%) and significant improvements in heart failure outcomes after one year, with 82.5% maintaining a lower grade of mitral regurgitation (MR).
- The findings indicate that LVGLS is a crucial factor in predicting cardiovascular mortality, particularly in patients with very low LVEF, suggesting its utility in identifying those at higher risk and optimizing treatment
Article Synopsis
- The study aimed to assess how tricuspid regurgitation (TR) changes in the short term after mitral valve repair (M-TEER) in patients with secondary mitral regurgitation (SMR), as well as the factors influencing these changes and their impact on mortality.
- Among 503 SMR patients, 35% showed improvements in TR after M-TEER, while 19% experienced worsening, and 46% remained unchanged; smaller left atrial size and minimal residual mitral regurgitation predicted better TR outcomes.
- Notably, patients who improved their TR had lower all-cause mortality rates over the long term, indicating that achieving TR ≤2+ post-M-TEER significantly reduces mortality risk
Article Synopsis
- RV-PA coupling is important for predicting outcomes in patients with secondary mitral regurgitation (SMR) undergoing transcatheter edge-to-edge mitral valve repair (M-TEER), but its changes post-procedure were previously unclear.
- The study found that 66% of patients showed improvement in RV-PA coupling (measured as TAPSE/PASP) after M-TEER, with several baseline factors predicting this improvement.
- Improved TAPSE/PASP after M-TEER was linked to lower rates of heart failure hospitalization and a decreased risk of long-term mortality, highlighting its prognostic value.
The present study exposes an economical and easy-to-use system to assess the heat transfer in building envelopes by determining the U-value. Nowadays these systems require long wires and a host to collect and process the data. In this work, a multi-point system for simultaneous heat flux measurement has been proposed.
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- Malnutrition is prevalent in patients undergoing transcatheter edge-to-edge mitral valve repair (TEER), with 74.4% showing some level of malnutrition, but only 20% classified as moderate-severe.
- In a study of 892 patients from the MIVNUT registry, moderate-severe malnutrition was found to significantly increase the risk of mortality (hazard ratio of 2.1) and heart failure admissions (subdistribution hazard ratio of 1.6) during a follow-up period averaging 1.6 years.
- The findings suggest that evaluating nutritional status in patients undergoing TEER could enhance risk assessment and potentially improve patient outcomes.
Background: Data on outcomes of transcatheter aortic valve replacement (TAVR) using balloon-expandable valves (BEVs) or self-expandable valves (SEVs) as well as the impact of center valve preference on these outcomes are limited.
Objectives: The aim of this study was to compare outcomes of TAVR procedures using third-generation BEVs and SEVs stratified by center valve preference.
Methods: In a multicenter registry (n = 17), 13 centers exhibited valve preference (66.
Left Atrial Appendage Occlusion in Hereditary Haemorrhagic Telangiectasia Patients (Rendu Osler Syndrome) With Non-Valvular Atrial Fibrillation: Prevention of Cardioembolic Events While Avoiding the Long-Term Risks of Oral Anticoagulation.
Cardiovasc Revasc Med
October 2022
Article Synopsis
- Hereditary haemorrhagic telangiectasia (HHT) is a genetic vascular disorder that can lead to bleeding and arteriovenous malformations, and its effects on patients with non-valvular atrial fibrillation (NVAF) undergoing left atrial appendage occlusion (LAAO) are not well-studied.
- This study involved 7 HHT patients who underwent LAAO between 2015 and 2020, with follow-ups indicating successful device implantation and no serious adverse events like strokes or thrombosis reported.
- The findings suggest that LAAO could be a beneficial non-medication option for reducing the risk of blood clots in HHT patients with NVAF.
Introduction And Objectives: Transcatheter edge-to-edge repair (TEER) should be considered in patients with heart failure and secondary mitral regurgitation (MR). Angiotensin receptor-neprilysin inhibitors (ARNIs) have been demonstrated to improve prognosis in heart failure. We aimed to evaluate the impact ARNIs on patient selection and outcomes.
View Article and Find Full Text PDFLow levels of proinflammatory cytokines in a transdiagnostic sample of young male and female early onset eating disorders without any previous treatment: A case control study.
Psychiatry Res
April 2022
Growing interest exists in the association of the immune system and its role in the development and maintenance of eating disorders (ED). Current evidence suggests that serum cytokine levels seem to be elevated in females with anorexia nervosa (AN). However, less is known in bulimia nervosa (BN) and other specified feeding and eating disorders (OSFED), specially in males.
View Article and Find Full Text PDFBackground: Risk stratification for transcatheter edge-to-edge mitral valve repair (TEER) is paramount in the decision-making process for treating severe mitral regurgitation (MR).
Objectives: This study sought to create and validate a user-friendly score (MitraScore) to predict the risk of mortality in patients undergoing TEER.
Methods: The derivation cohort was based on a multicentric international registry that included 1,119 patients referred for TEER between 2012 and 2020.