Impact of a Disease-Focused Electronic Health Record Dashboard on Clinical Staff Efficiency in Previsit Patient Review in an Ambulatory Pulmonary Hypertension Care Clinic.

Objectives:  We aimed to improve the operational efficiency of clinical staff, including physicians and allied health professionals, in the previsit review of patients by implementing a disease-focused dashboard within the electronic health record system. The dashboard was tailored to the unique requirements of the clinic and patient population.

Methods:  A prospective quality improvement study was conducted at an accredited pulmonary hypertension (PH) clinic within a large academic center, staffed by two full time physicians and two allied health professionals.

Spermatogonial stem cell technologies: applications from human medicine to wildlife conservation†.

Spermatogonial stem cell (SSC) technologies that are currently under clinical development to reverse human infertility hold the potential to be adapted and applied for the conservation of endangered and vulnerable wildlife species. The biobanking of testis tissue containing SSCs from wildlife species, aligned with that occurring in pediatric human patients, could facilitate strategies to improve the genetic diversity and fitness of endangered populations. Approaches to utilize these SSCs could include spermatogonial transplantation or testis tissue grafting into a donor animal of the same or a closely related species, or in vitro spermatogenesis paired with assisted reproduction approaches.

Aesthetic management of lips and perioral region with Hylacross® and Vycross® hyaluronic-acid based fillers: A document of recommendations.

Background: Lip volumization and perioral rejuvenation with hyaluronic-acid (HA) based dermal fillers are generating increasing interest and demand. However, this topic is still having many unmet needs nowadays. This document aimed to provide tips and recommendations that may help clinicians to achieve optimal and more predictable aesthetic outcomes.

Hysteroscopic subchorionic injection of methotrexate followed by laparoscopic excision of the gestational sac for the management of cesarean scar ectopic pregnancy: an innovative dual approach of a challenging pathology.

Objective: To describe an effective two-step surgical approach for the management of cesarean scar ectopic pregnancies (CSEPs). CSEPs occur at an estimated frequency of 1 in 1,800 pregnancies, constituting approximately 6% of ectopic pregnancies in women with a history of prior cesarean delivery [1, 2]. Despite numerous recommended therapeutic approaches, the most effective treatment strategy remains uncertain [3].

Peripheral arterial disease in hemodialysis patients 10 years later.

Background And Objective: Patients with chronic kidney disease (CKD) on hemodialysis present high cardiovascular comorbidity. Peripheral arterial disease (PAD) is associated with higher mortality and the interest in its early detection and treatment is increasing. The objective of this study is to determine the frequency and severity of symptomatic PAD, and to establish its relationship with mortality in HD patients that have received treated early and compare them with a cohort of our center already reported.

Second-order semi-aplanatic freeform optics as a limit case of the SMS 3D design method.

Second-order semi-aplanatism provides better imaging quality along a line of the object plane close to a point than conventional aplanatic optics, which is of interest in applications with high aspect ratio sensors. Designing an optic with second-order semi-aplanatism requires the use of freeform surfaces, and can be done as a limit case of the SMS 3D design method applied to stigmatically image 3 collinear object points. The algorithm for this specific design problem is described and a lens example with 3 freeform surfaces is designed and analyzed.

COVID-19, science, vaccines and family in a multi origin Latinx population in South Florida.

During the Spring of 2021 in Miami-Dade County, four virtual focus groups were held with 31 participants from four diverse local Latinx communities as part of the Florida Community Engagement Alliance (FL-CEAL) Against COVID-19 Disparities project. The main objective was to explore attitudes about COVID-19 information and prevention strategies among South Florida's diverse Latinx populations, across a broad geographical area. The study used a semi-structured focus group qualitative design and chose participants from four well established Latinx neighborhoods.

Effectiveness of an individualized comprehensive rehabilitation program in women with chronic knee osteoarthritis: a randomized controlled trial.

Objective: To evaluate the short- and medium-term effects of an 8-week individualized comprehensive rehabilitation program in women with chronic knee osteoarthritis as regards functionality, physical performance, and perceived health status.

Methods: Women with chronic knee osteoarthritis were randomly assigned to the aquatic training group or to the individualized comprehensive rehabilitation (ICR) group. The main outcomes were functionality assessed with the Western Ontario and McMaster Universities Osteoarthritis Index, physical performance assessed with the Timed Up and Go test and the Stair Climbing Test, and perceived health status evaluated with the European Quality of Life- 5 Dimensions questionnaire.

An expert consensus report on the clinical use of the Vycross hyaluronic acid VYC-25 L filler.

Background: The portfolio of hyaluronic acid (HA) fillers and the techniques of administration have evolved in recent years. The latest innovation in the Vycross range was the introduction of VYC-25L (Juvéderm Volux ; Allergan plc), a first-in-class filler effective for chin and facial lower third remodeling. The aim here was to provide clinicians who are starting to use VYC-25L with key advice, and to standardize procedures so that optimal and predictable outcomes can be obtained.

Omission of Axillary Lymph Node Dissection is Associated with Inferior Survival in Breast Cancer Patients with Residual N1 Nodal Disease Following Neoadjuvant Chemotherapy.

Background: The appropriateness of substituting sentinel lymph node dissection (SLND) and regional nodal irradiation (RNI) for axillary lymph node dissection (ALND) in patients with residual lymph node (LN) disease following neoadjuvant chemotherapy (NAC) is unknown. We used the National Cancer Database (NCDB) to compare survival following SLND and ALND in breast cancer patients with residual LN disease.

Methods: We analyzed NCDB patients, treated between 2006 and 2014, with cT1-3, cN1, cM0 breast cancer and residual disease in 1-3 axillary LNs (ypN1) following NAC.

COVID-19: clinical course and outcomes of 36 hemodialysis patients in Spain.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia emerged in Wuhan, China in December 2019. Unfortunately, there is a lack of evidence about the optimal management of novel coronavirus disease 2019 (COVID-19), and even less is available in patients on maintenance hemodialysis therapy than in the general population. In this retrospective, observational, single-center study, we analyzed the clinical course and outcomes of all maintenance hemodialysis patients hospitalized with COVID-19 from March 12th to April 10th, 2020 as confirmed by real-time polymerase chain reaction.

Effects of Gender and Body Weight on Children's Peer Choice During Physical Activities.

The present study investigated possible effects of gender and body weight on children's peer choices during physical activities. Twenty-four school-aged children (12 overweight and 12 non-overweight) were observed during 2 play sessions: the 1st session consisted of 2 tests that required agility (A) and 1 that required strength (S) in an A-S-A design; the 2nd session consisted of 2 strength tests and 1 agility in an S-A-S design. Before each session, 2 participants were asked to choose members for their teams.

[Mental health in general hospitals of the City of Rosario and Great Rosario, Argentina].

Eight years after the enactment of the National Mental Health Law (26.657), we consider it necessary to build spaces for debate on the potentialities and challenges in its practical implementation. This research addresses the mental health practices in the general public hospitals of the city of Rosario and Gran Rosario, Argentina, from the workers' perspective.

SMS2D designs as starting points for lens optimization.

Traditional imaging design methods can often be ineffective when designing aspheric systems because of the large number of optimization parameters and lack of a good starting point. They are often trapped in a poor local minimum and it can be highly time-consuming to find a good solution in a bumpy design landscape. The simultaneous multiple surface (SMS) method can significantly shorten the time and effort needed to find a desired solution by providing a starting point to optimize close to a good local minimum.

Fast, deterministic computation of irradiance values using a single extended source in 3D.

Presented is a quasi-analytic method for irradiance evaluation through a single refractive surface from a single Lambertian source. The method is compared to Monte-Carlo raytracing for a sample system, producing in much less time an irradiance distribution equal to within the latter's statistical noise. In addition to its interest to optical analysis, the method is also useful for optical design problems by allowing for fast, noise-free evaluation of merit functions, along with their derivatives.

Mutational landscape of radiation-associated angiosarcoma of the breast.

Purpose: Radiation-associated breast angiosarcomas are a rare complication of radiation therapy for breast carcinoma. With relatively little is known about the genetic abnormalities present in these secondary tumors, we examined genomic variation in biospecimens from radiation-associated breast angiosarcomas.

Experimental Design: Patients were identified that had a previous breast cancer diagnosis, received radiation therapy, and developed angiosarcoma in the ipsilateral breast as the earlier cancer.

Compact illumination optic with three freeform surfaces for improved beam control.

Multi-chip and large size LEDs dominate the lighting market in developed countries these days. Nevertheless, a general optical design method to create prescribed intensity patterns for this type of extended sources does not exist. We present a design strategy in which the source and the target pattern are described by means of "edge wavefronts" of the system.

Three surface freeform aplanatic systems.

We address, in detail, the system of differential equations determining a freeform aplanatic system with illustrative examples. We also demonstrate how two optical surfaces, in general, are insufficient in achieving freeform aplanatism through the use of integrability condition for a given reflective freeform aplanatic configuration. This result also alludes to the fact that a freeform aplanatic system fulfills a broader set of conditions than its rotationally symmetric counterpart.

Six-Year Results From a Phase I/II Trial for Hypofractionated Accelerated Partial Breast Irradiation Using a 2-Day Dose Schedule.

Background: To report 6-year outcomes from a phase I/II trial using balloon-based brachytherapy to deliver APBI in 2 days.

Methods: A total of 45 patients with early-stage breast cancer received adjuvant APBI in 2 days with high-dose rate (HDR) brachytherapy totaling 2800 cGy in 4 fractions (700 cGy BID) using a balloon-based applicator as part of a prospective phase I/II clinical trial. All patients had negative margins and skin spacing ≥8 mm.

Analytical solution of an afocal two freeform mirror design problem.

We investigate a new afocal two freeform mirror design problem in first order optics. The resulting first-order partial differential equations for the freeform two mirror system have an analytic solution with the sole condition that the x-y and x'-y' axes are parallel. Two selected solutions are presented.

YAP-dependent mechanotransduction is required for proliferation and migration on native-like substrate topography.

Native vascular extracellular matrices (vECM) consist of elastic fibers that impart varied topographical properties, yet most in vitro models designed to study the effects of topography on cell behavior are not representative of native architecture. Here, we engineer an electrospun elastin-like protein (ELP) system with independently tunable, vECM-mimetic topography and demonstrate that increasing topographical variation causes loss of endothelial cell-cell junction organization. This loss of VE-cadherin signaling and increased cytoskeletal contractility on more topographically varied ELP substrates in turn promote YAP activation and nuclear translocation, resulting in significantly increased endothelial cell migration and proliferation.

Freeform aplanatic systems as a limiting case of SMS.

We present here aplanatic systems in 3D geometry as a limiting case of a SMS 3D design. We extend the basic formulations governing rotationally symmetric aplanatic systems to freeform aplanatic systems and provide a formal proof that a SMS 3D design in the limiting case of 3 coincident points leads to a freeform aplanatic system.