Publications by authors named "Benita J Myles"
The effects of methamphetamine on core body temperature in the rat--part 2: an escalating regimen.
Psychopharmacology (Berl)
June 2008
Rationale: Methamphetamine (METH) induces hyperthermia, which is diminished with chronic treatment in a dose-dependent manner. Our objective was to determine whether the temperature responses produced by a chronic, escalating-dose METH regimen and a chronic, 5.0 mg/kg dose regimen.
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- The study examines how methamphetamine (METH) affects core body temperature, focusing on how tolerance develops with chronic use and the role of ambient temperature.
- Rats were treated with varying doses of METH in controlled temperature settings, and their core temperatures were monitored for 12 days to assess changes over time and under different conditions.
- Findings indicate that peak temperature responses to METH occur at different times based on dosage, that chronic use leads to reduced temperature responses not linked to long-term neurochemical changes, and that the temperature response is characterized by two distinct phases due to different underlying mechanisms.