Publications by authors named "Benit T Ikulinda"
Background: Routine childhood immunisation with pneumococcal conjugate vaccine (PCV) has changed the epidemiology of pneumococcal disease across age groups, providing an opportunity to reconsider PCV dosing schedules. We aimed to evaluate the post-booster dose immunogenicity of ten-valent (PCV10) and 13-valent (PCV13) PCVs between infants randomly assigned to receive a single-dose compared with a two-dose primary series.
Methods: We did an open-label, non-inferiority, randomised study in HIV-unexposed infants at a single centre in Soweto, South Africa.
Article Synopsis
- - The study evaluated the immunogenicity and safety of a single dose of inactivated hepatitis-A virus (HAV) vaccine and live attenuated varicella zoster virus (VZV) vaccine in South African children, including both HIV-exposed uninfected (HEU) and HIV-unexposed children.
- - After vaccination, 91.8% of HIV-unexposed and 82.9% of HEU children tested positive for hepatitis-A antibodies, while VZV antibody responses were similar, but seroconversion rates were lower than previous studies at only 44%.
- - Adverse events were reported at similar frequencies between the groups, although HEU children experienced more systemic adverse effects after VZ
Article Synopsis
- Measles risks are highest in children under 12 months old, especially those exposed to HIV, prompting a study on a 2-dose vaccine regimen in South Africa.
- The study involved vaccinating HIV-unexposed (HU) and HIV-exposed, uninfected (HEU) children at 6 and 12 months, measuring their antibody responses before and after vaccination.
- Results showed significant improvement in measles immunity post-vaccination, with safety profiles being comparable between both groups, indicating the vaccination may help protect infants losing maternal antibodies.