Toxoplasmosis is a common zoonotic disease that poses serious global health risks, particularly neurotoxoplasmosis, which has a high mortality rate.
This study tested the effectiveness of nitazoxanide on mice infected with neurotoxoplasmosis, comparing it to the standard treatment of pyrimethamine plus sulfadiazine.
Results showed that while nitazoxanide reduced parasitic load and had similar toxicity to standard treatment, it was less effective overall, making pyrimethamine and sulfadiazine the preferred option for treating this condition.