[Somatotropic function of the pituitary gland in patients with genetically determined forms of growth retardation].

Altogether 144 patients with various forms of retardation of growth aged 1 to 24 were investigated. Somatotropic function of the pituitary body was assessed by the results of a stimulation test with clopheline. A STH level was determined by a radioimmunoassay.

[The transplantation of beta-cell cultures in the treatment of insulin-dependent diabetes mellitus in children].

Over 100 transplantations were performed in 86 children and adolescents with a severe course of insulin dependent diabetes mellitus. A good effect was achieved in 81 +/- 6%, in other cases the effect was uncertain. Therapy resulted in a significantly higher rate of cases of stable compensation with a lesser number of injections and a stable dose of insulin, in stabilization and regression of some complications.

[Characteristics of the course of pregnancy and labor in women with Cushing's syndrome and the condition of their progeny].

An analysis of gestational and obstetric histories of 40 women with Cushing's disease has shown that pregnancy is contraindicated during an active phase or partial clinical remission of the disease. Pregnancy is permissible at a prolonged time following the onset of a stable clinical and hormonal remission, bilateral total adrenalectomy and compensation of chronic adrenal insufficiency. No specific therapy is required in the former situation.

[Tactics of examining patients with unpalpable testis redux].

As many as 117 patients with inpalpable testis redux were examined. They had undergone selective testicular venography with measurements of testosterone content in random blood samples after stimulation with human chorionic gonadotropin. The data obtained during all-round investigation make it possible to estimate the morphological status of the testes and their functional reserves.

[The use of klofelin for studying somatotropin secretion in children].

A stimulation clonidine test was performed in children for a study of STH secretion. The drug was injected at a dose of 0.15 m per 1 m2 of body surface.

[Contents of gonadotropic and sex hormones in the blood of healthy children].

The blood content of follicle-stimulating, luteinizing hormones, prolactin, testosterone and estradiol was measured in 343 normal children (181 boys and 162 girls) aged 1 month to 16 years by radioimmunoassay with the aid of standard commercial kits. Standardized age- and sex-associated indicators have been elaborated. The time-course of changes in the hormonal content during puberty has been characterized.

[Problems of pathogenesis of ovarian and idiopathic hirsutism].

The content of total testosterone (T), dehydrotestosterone (DHT), androstenedione (A), estradiol (E2), luteotropin (LH) and follicle-stimulating hormone (FSH) was studied in patients with ovarian and idiopathic hirsutism by a radioimmunoassay. The level of T-E-binding globulin (TEBG) was determined by 3H-DHT binding. Concentrations of free and TEBG-unbound T, DHT and E2 were calculated on the basis of the mass action law.

[Characteristics of prolactin secretion in patients with different types of gonadal dysgenesis].

A study was made of the level of prolactin in the blood plasma of 55 patients aged 16 to 23 with different types of gonad dysgenesia. It was shown for the first time that in most of the patients with gonad dysgenesia disregarding pathology type the level of prolactin did not differ from that in the follicular phase of the menstrual cycle of healthy girls, and was significantly decreased as compared to the level of this hormone in the luteal phase. Estrogen therapy caused a considerable rise of the prolactin level in all the examines.

[Experience with the treatment of children with diabetes mellitus using allo- and xenografts of cultures of pancreatic islet cells].

The paper is concerned with the study of the results of allo- and xenotransplantation of pancreatic islet cell culture to 44 children aged 1.5 to 15 suffering from a severe form of insulin dependent diabetes mellitus. An impossibility to achieve stable compensation of disease with routine therapy and complications of diabetes mellitus were the main indications for transplantation.

[Use of the antiandrogen niftolide for studying reserves of the hypothalamo-hypophyseal system in patients with male hypogonadism].

A study was made of a possibility to use a test with the administration of the nonsteroid antiandrogen flutamide to male patients with testicular hypogonadism to evaluate the gonadotropic reserves in this pathology and differential diagnosis of the pathogenetically different forms of this diseases in male patients aged 12 to 33. Flutamide was prescribed for internal use, 10 mg/kg a day for 5 days. Functional reserves of the hypothalamo-hypophyseal-gonadal system were estimated by the change of LH secretion with morning and daily urine after 3 and 5 days as well as by the LH, FSH and T content in the blood plasma.

[New functional test using the antiandrogen niftolid for studying the gonadotropic reserves of the hypothalamo-hypophyseal system].

A study was made of a possibility to use a nonsteroidal antiandrogen flutamide to investigate the gonadotropic reserves of the hypothalamo-hypophysial system. In healthy males aged 12 to 36, the intake of flutamide tablets at a dose of 10 mg/kg bw for 3 or 5 days was accompanied by an increase in the LH excretion and general gonadotropic activity in the daily urine by 1.5-2 times and more.

[Gonadotropic function of the pituitary gland in patients with intersexualism and gonadal dysgenesis].

Radioimmunoassay was used to study the blood content of LH and FSH in 116 patients aged 1 to 36 years with abnormalities of sexual development (false male hermafroditism, false female hermafroditism, true hermafroditism and gonadal dysgenesis). With a view of control the content of gonadotropins was measured in 92 subjects (33 females and 59 males) of the same age. The data were evaluated in accordance with the age and genetic sex of patients.

[Detection of the heterozygote carrier state for the gene of congenital virilizing adrenal cortical hyperplasia by the blood testosterone level].

The study of genealogy of the families with cases of congenital adrenocortical virilizing hyperplasia allowed one to suggest a possibility of the heterozygous bearing of a pathological gene. The investigation of the plasma testosterone level in the parents of children with the adrenogenital syndrome has shown that an increase in the blood circulating testosterone level 1.6 to 4 times compared with normal may serve as a marker of heterozygosis for this disease.

[Genitography in intersexuality].

Genitography was performed in 60 patients with different sexual abnormalities. The main types of the structure of external and internal genitals were revealed. Genitography can be used in any age, including the 1st year of life.