Publications by authors named "Beneton N"
Background: New highly effective drugs for moderate-to-severe cutaneous psoriasis are regularly marketed, and the hierarchy of treatments thus requires frequent review.
Objectives: A Delphi method was used to enable a structured expert consensus on the use of systemic treatments and phototherapy among adults with moderate-to-severe psoriasis.
Methods: The Delphi method consists in achieving a convergence of opinions among a panel of experts using several rounds of questionnaires with controlled feedback between rounds.
Acne in adult females is triggered mainly by hormones. Doxycycline is a reference treatment in acne. Spironolactone targets the androgen receptor of sebaceous glands and is prescribed off-label for female adult acne.
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- The Ritux 3 trial showed that rituximab is effective and safe as a first-line treatment for pemphigus, although long-term follow-up data was previously lacking.!* -
- This 7-year follow-up study evaluated the long-term outcomes for patients treated with rituximab alongside prednisone versus those treated with prednisone alone, focusing on disease-free survival and relapse rates.!* -
- Results indicated that 93% of patients in the rituximab group achieved complete remission without corticosteroids, showing significantly higher disease-free survival and lower relapse rates compared to the prednisone-only group.!*
Background: Nailfold capillaroscopy is recommended to diagnose primary or secondary Raynaud's phenomenon (RP). Capillaroscopy is normal in primary RP, which is the most frequent. Screening for RP capillary anomalies with nailfold dermoscopy has been promising.
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- - Merkel cell carcinoma (MCC) is often linked to the Merkel cell polyomavirus (MCPyV), particularly when the virus integrates into the host's DNA and leads to mutations in the Large T antigen (LT), which is essential for the virus's cancer-causing properties.
- - In recent cases involving MCC combined with skin tumors called trichoblastoma and poroma, researchers found evidence of MCC developing from epithelial cells and identified both mutated and wild-type LT sequences.
- - The findings indicate that some MCC cases may contain intact MCPyV genomes and express certain viral proteins, suggesting a more complex interaction between the virus and cancer than previously understood.
Data regarding elderly melanoma patients treated with anti-PD-1 or anti-CTLA-4 antibodies are in favor of tolerability outcomes that are similar to those of younger counterparts. However, there are very few studies focusing on elderly patients receiving nivolumab combined with ipilimumab (NIVO + IPI). Here, we ask what are the current prescribing patterns of NIVO + IPI in the very elderly population and analyze the tolerance profile.
View Article and Find Full Text PDFBackground: Plasma cell gingivitis is defined as gingival inflammation comprised of plasma cell infiltrates. This diagnostic criterion is non-specific and underlying mechanisms remain unknown.
Objectives: We performed a multidisciplinary clinico-pathological review of cases previously identified as "gingivitis with plasma cell infiltrates", with assessment of putative contributing factors and critical appraisal of the final diagnosis.
Background: Little is known about phototype and the response to systemic treatment in psoriasis.
Objectives: To assess the characteristics of psoriasis, the therapeutic choice and its efficacy according to phototype.
Methods: We included patients from the PsoBioTeq cohort initiating a first biologic.
Background: In areas of low physician density, especially as regards dermatologists in France, there is an increasing interest in tele-expertise. This is particularly the case in the Sarthe department, where the number of physicians continues to decline and access to care was further limited by the COVID 19 epidemic.
Study Design: We retrospectively collected data from tele-expertise requests submitted to Le Mans General Hospital by general practitioners via a dedicated platform between May 6, 2019, and April 9, 2021.
Merkel cell carcinoma (MCC) is an aggressive skin cancer for which Merkel cell polyomavirus integration and expression of viral oncogenes small T and Large T have been identified as major oncogenic determinants. Recently, a component of the PRC2 complex, the histone methyltransferase enhancer of zeste homolog 2 (EZH2) that induces H3K27 trimethylation as a repressive mark has been proposed as a potential therapeutic target in MCC. Because divergent results have been reported for the levels of EZH2 and trimethylation of lysine 27 on histone 3, we analyzed these factors in a large MCC cohort to identify the molecular determinants of EZH2 activity in MCC and to establish MCC cell lines' sensitivity to EZH2 inhibitors.
View Article and Find Full Text PDFBackground: The nature of the COVID-19 pandemic led to concerns among patients and physicians about the potential impact of immunosuppressive treatments for chronic diseases such as psoriasis on the risk of severe COVID-19.
Objectives: To describe treatment modifications and determine the incidence of COVID-19 infection among psoriasis patients during the first wave of the pandemic, and identify the factors associated with these events.
Methods: Data from PSOBIOTEQ cohort relating to the first COVID-19 wave in France (March to June, 2020), as well as a patient-centred COVID-19 questionnaire, were used to evaluate the impact of lockdown on changes (discontinuations, delays or reductions) in systemic therapies, and to determine the incidence of COVID-19 cases among these patients.
Introduction: Despite the existence of multiple assessment scores for psoriasis severity, skin disease with limited skin lesions but significant impairment of quality of life can be difficult to classify, leading to under- or overtreatment. Our objective was to obtain consensus on clinical criteria to classify psoriasis severity in French clinical practice, with a focus on moderate disease, using a modified Delphi method.
Methods: A steering committee (SC) formulated a 22-item questionnaire to classify moderate psoriasis.
Switches between biologics in patients with moderate-to-severe psoriasis: results from the French cohort PSOBIOTEQ.
J Eur Acad Dermatol Venereol
November 2022
Article Synopsis
- The study investigates the switching patterns between biologics in patients with moderate-to-severe plaque psoriasis, highlighting how these patterns have evolved with the introduction of new biologic treatments.
- In a cohort of 2,153 patients, it was found that 34% switched their first biologic within three years, primarily due to loss of efficacy (72%), with adalimumab and ustekinumab being the most commonly used agents.
- The research indicates that switching behaviors differ over time; for example, patients switching after 2016 were more likely to transition to IL-17 inhibitors rather than sticking with TNF-alpha inhibitors, signaling a shift in treatment preferences.
Purpose: Hidradenitis suppurativa (HS) is an inflammatory skin disease characterized by recurrent or chronic painful and suppurating lesions in the apocrine gland-bearing regions. The lack of knowledge about HS and its extremely heterogeneous clinical presentation, in terms of both lesion appearance and sites of involvement, frequently delay its diagnosis for several years. Objectives: in this study, using the latent class analysis, it was demonstrated that severity of HS could be evaluated not only with clinical or surgical characteristics but also with gender specificities.
View Article and Find Full Text PDFPaediatric psoriasis has been associated with school absenteeism, limitation of physical activities, psychiatric disorders and, in the longer term, with sexual dysfunction and addictions. This raises the hypothesis that childhood onset psoriasis may affect patients' educational development, and further social and professional outcomes. This study evaluated the relationship between childhood onset psoriasis and patients' educational and socioeconomic characteristics, and the development of addictions in adulthood.
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- Merkel cell carcinoma (MCC) is a serious skin cancer linked to the Merkel cell polyomavirus (MCPyV) in 80% of cases, with the remaining 20% associated with UV exposure; both types involve the inactivation of the RB1 gene leading to increased SOX2 expression.
- In a study of 196 MCC tumors, it was found that RB1 loss was present in 27% of MCC cases, indicating a strong correlation with MCPyV-negative status, whereas MCPyV-positive cases remained RB1-positive.
- SOX2 was shown to be a key diagnostic marker, with 92% of MCC tumors expressing it diffusely compared to only 2% in non-neuro
Article Synopsis
- The study investigates how the availability of new systemic treatments affects drug survival in patients with moderate to severe psoriasis.
- Researchers analyzed data from 1,866 patients in a French cohort, looking specifically at those starting their first biological or synthetic disease-modifying antirheumatic drugs.
- Results showed no significant correlation between the year a patient started treatment and the effectiveness or safety of the drug, indicating that drug survival remains stable over time despite more treatment options.
Article Synopsis
- Cemiplimab has shown promise in real-world use for locally advanced and metastatic cutaneous squamous-cell carcinomas (CSCCs), with a best overall response rate of 50.4% among treated patients.
- There was a median progression-free survival (PFS) of 7.9 months, and one-year overall survival (OS) was 73% for patients with better performance status (PS < 2).
- Although some patients experienced severe adverse events, the overall safety and efficacy indicate cemiplimab may be a beneficial treatment option, especially for immunocompromised individuals.