Publications by authors named "Benedicte Noblet"
Objective: Circulating tumour DNA (ctDNA) is a promising non-invasive biomarker in cancer. We aim to assess the dynamic of ctDNA in patients with hepatocellular carcinoma (HCC).
Design: We analysed 772 plasmas from 173 patients with HCC collected at the time of diagnosis or treatment (n=502), 24 hours after locoregional treatment (n=154) and during follow-up (n=116).
TxNIP (Thioredoxin-interacting protein) is considered as a potential drug target for type 2 diabetes. Although TxNIP expression is correlated with hyperglycemia and glucotoxicity in pancreatic β cells, its regulation in liver cells has been less investigated. In the current study, we aim at providing a better understanding of regulation in hepatocytes in response to physiological stimuli and in the context of hyperglycemia in mice.
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- Telomerase activation is crucial in the early stages of hepatocellular carcinoma (HCC) development, with research focusing on how telomere length maintenance affects liver cancer progression.
- A study involving 1,502 patients analyzed telomere lengths, TERT gene alterations, and various clinical features, leading to insights about factors like aging and alcohol consumption that influence liver telomere shortening.
- The research found that longer telomeres were linked to aggressive HCC types with poor prognoses and demonstrated that anti-TERT antisense oligonucleotides could effectively halt cancer cell proliferation in laboratory settings and mouse models, indicating a potential therapeutic approach.
The Wnt/β-catenin pathway plays a pivotal role in liver structural and metabolic homeostasis. Wnt activity is tightly regulated by the acyltransferase Porcupine through the addition of palmitoleate. Interestingly palmitoleate can be endogenously produced by the stearoyl-CoA desaturase 1 (SCD1), a lipogenic enzyme transcriptionally regulated by insulin.
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- The study focuses on a specific genetic alteration, DNAJB1-PRKACA fusion, in fibrolamellar carcinoma (FLC), a rare liver cancer seen mainly in younger individuals, and explores the molecular characteristics of mixed FLC/HCC tumors in older patients.
- Researchers analyzed 151 liver tumors through sequencing techniques to identify mutations and patterns, finding a distinct group of mixed-FLC/HCC tumors that often had inactivated BAP1 gene, which is linked to cancer progression.
- The discovery reveals that BAP1 tumors share similarities with FLC, showing certain immune features and dysregulation in the PKA pathway, suggesting a potential link between these two types of liver cancer.
Relapsed and metastatic hepatoblastoma represents an unmet clinical need with limited chemotherapy treatment options. In a chemical screen, we identified volasertib as an agent with activity, inhibiting hepatoblastoma cell growth while sparing normal hepatocytes. Volasertib targets PLK1 and prevents the progression of mitosis, resulting in eventual cell death.
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