Publications by authors named "Benedicte Grebstad Tune"
Genetic histone variants have been implicated in cancer development and progression. Mutations affecting the histone 3 (H3) family, H3.1 (encoded by and ) and H3.
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- Birth asphyxia is a leading cause of mortality and disability in children globally, with long non-coding RNAs (lncRNAs) presenting potential targets for new treatments due to their regulatory functions.
- A study using piglets examined key lncRNAs involved in oxidative stress and related processes, dividing 42 newborn subjects across four experimental conditions including varying reoxygenation methods after hypoxia.
- Results showed that exposure to hypoxia significantly affected lncRNA transcription levels, suggesting that these molecules play a crucial role in the brain's response to damage from perinatal asphyxia and could lead to future therapeutic strategies.
Background: Since the discovery more than half a century ago, cell-free DNA (cfDNA) has become an attractive objective in multiple diagnostic, prognostic, and monitoring settings. However, despite the increasing number of cfDNA applications in liquid biopsies, we still lack a comprehensive understanding of the nature of cfDNA including optimal assessment. In the presented study, we continued testing and validation of common techniques for cfDNA extraction and quantification (qRT-PCR or droplet digital PCR) of nuclear- and mitochondrial cfDNA (ncfDNA and mtcfDNA) in blood, using a piglet model of perinatal asphyxia to determine potential temporal and quantitative changes at the levels of cfDNA.
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