Publications by authors named "Benedicte Binet"
Upon activation, naive CD4 T cells differentiate into distinct T cell subsets via processes reliant on epigenetically regulated, lineage-specific developmental programs. Here, we examined the function of the histone methyltransferase SETDB1 in T helper (Th) cell differentiation. Setdb1 naive CD4 T cells exhibited exacerbated Th1 priming, and when exposed to a Th1-instructive signal, Setdb1 Th2 cells crossed lineage boundaries and acquired a Th1 phenotype.
View Article and Find Full Text PDFArticle Synopsis
- Most T lymphocytes, like regulatory T cells (Treg cells), are made in a special part of the body called the thymus.
- As we get older, the thymus gets smaller and doesn't produce as many T cells, especially Treg cells.
- Some Treg cells travel back to the thymus and help control how many new Treg cells are made by stopping their production.