Publications by authors named "Benedict See"
Adv Sci (Weinh)
November 2023
Article Synopsis
- Metastasis in cancer is linked to a process called epithelial-to-mesenchymal transition (EMT), which involves complex gene networks that can potentially be disrupted for therapeutic benefits.
- Researchers identified key hub genes, particularly YWHAG, which is crucial in various human cancers and regulates responses during EMT by enhancing cellular protection against oxidative stress through autophagy.
- YWHAG deficiency leads to increased oxidative stress, slower EMT, and cell death, while high YWHAG levels correlate with greater metastasis and improved survival in tumor models, suggesting its potential as a target for cancer treatment.
