Publications by authors named "Benedict J E Monteiro"
Article Synopsis
- - Cells without p53 signaling are common in ulcerative colitis (UC) and play a key role in the development of colorectal cancer linked to UC.
- - Epithelial injury during colitis triggers stem cells to shift to a "fetal-like" regenerative state, which is regulated by p53 signaling during colitis but not during normal conditions.
- - The study shows that while p53 is crucial in stopping excessive regeneration in healthy cells during injury, cells lacking p53 continue proliferating due to altered glycolysis processes, which helps explain their prevalence in UC and related cancers.
Cancer Discov
October 2021
Article Synopsis
- Pediatric liver cancers (PLC) are diverse diseases that affect younger populations, showing varying responses to chemotherapy despite generally favorable outcomes.
- A genomic study of 126 pediatric liver tumors revealed new targetable oncogenes and identified a specific premalignant cell expansion in 10% of hepatoblastoma patients younger than three years old.
- Research highlighted the accumulation of mutations in "liver progenitor" cells during chemotherapy, leading to cisplatin resistance, and validated promising new treatments through drug screening and xenograft experiments.
