Antimicrobial Metabolites against Methicillin-Resistant from the Endophytic Fungus .

Antimicrobial bioassay-guided fractionation of the endophytic fungi led to the isolation of a new unsymmetrical naphthoquinone dimer, neofusnaphthoquinone B (), along with four known natural products (-). Structure elucidation was conducted by nuclear magnetic resonance (NMR) spectroscopic methods, and the antimicrobial activity of all the natural products was investigated, revealing to be moderately active towards methicillin-resistant (MRSA) with a minimum inhibitory concentration (MIC) of 16 µg/mL.