Publications by authors named "Benedetta Zanetti"
Article Synopsis
- Mucosal Melanomas (MM) are super aggressive cancers that arise in certain skin cells, and current treatments aren't helping much for advanced cases.
- Scientists created five new cell lines (named SN-MM1-5) from patient samples to better study and understand these cancers, testing how they behave in lab experiments and in mice.
- The study found that these new cell lines showed important differences from normal cells and identified specific cancer-related features, helping researchers learn more about how to treat mucosal melanomas better.
Urothelial bladder cancer (UBC) are classified into luminal and basal subtypes showing distinct molecular features and clinical behaviour. Recent in silico data have proposed the activation on the Signal Transducer and Activator of Transcription 3 (STAT3) as relevant transcription factor in UBC. To answer this question, we have combined the retrospective analysis of clinical samples, functional assays on cell lines, interrogation of public UBC datasets and a murine model of basal-type UBC.
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