Publications by authors named "Benedetta Vignati"
Behavioral Alterations of Spatial Cognition and Role of the Apolipoprotein E-ε4 in Patients with MCI Due to Alzheimer's Disease: Results from the BDSC-MCI Project.
Davide Maria Cammisuli Virginia Bellocchio Alessandra Milesi Edoardo Nicolò Aiello Barbara Poletti Benedetta Vignati
J Clin Med
September 2024
Article Synopsis
- The study investigates how spatial disorientation and behavioral issues in spatial cognition manifest in prodromal Alzheimer's disease (AD) compared to normal aging and mild cognitive impairment (MCI).
- A sample of 58 elderly participants, including those with mild cognitive impairment, subjective cognitive decline, and healthy controls, was tested using the Detour Navigation Test and smartphone GPS tracking to assess wrong turns and gait patterns.
- Results indicated that MCI patients made more wrong turns than the other groups, and the presence of the ApoE-ε4 genotype was linked to poorer spatial processing and slower gait in real-world navigation tasks.
Behavioral Disorders of Spatial Cognition in Patients with Mild Cognitive Impairment Due to Alzheimer's Disease (The BDSC-MCI Project): Ecological Validity of the Corsi Learning Suvra-Span Test.
Davide Maria Cammisuli Gloria Marchesi Virginia Bellocchio Edoardo Nicolò Aiello Barbara Poletti Benedetta Vignati
J Pers Med
May 2024
Article Synopsis
- The study investigates how deficits in visuospatial long-term memory can forecast navigation difficulties in older adults as they progress from normal aging to Alzheimer's disease (AD).
- It involved assessing 72 participants, including those with Mild Cognitive Impairment (MCI), subjective cognitive decline (SCD), and healthy controls, using a navigation test and a learning task to measure performance.
- Results indicated that higher performance in the learning task correlated with fewer navigation mistakes and hesitations, suggesting the potential of the learning test as a tool for evaluating navigational abilities in individuals at risk for AD.
Article Synopsis
- Spatial cognition impairment is one of the first signs of Alzheimer's disease, leading to spatial disorientation even in familiar areas, and there are few studies examining this in early stages of Alzheimer's using real-world testing.
- The study involved 20 patients with Mild Cognitive Impairment (MCI) due to AD and 20 age-matched controls, assessing their navigation abilities through a modified Detour Navigation Test (DNT-mv).
- Results indicated that MCI patients made more wrong turns and hesitated more during navigation tasks, correlated with cardiac autonomic nervous system changes, highlighting the potential for using real-world navigation tasks to detect early signs of spatial disorientation in Alzheimer's.