Publications by authors named "Benedetta Turri"
Pharmaceuticals (Basel)
January 2021
Article Synopsis
- Protopine (PRO) shows anticancer properties and was tested with gemcitabine (GEM) on tumor and non-tumor cells, revealing varying cytotoxic and cytoprotective effects.
- In pancreatic cancer cells (MIA PaCa-2 and PANC-1), PRO/GEM combinations reduced cell viability, while helping normal dermal fibroblasts (HDFs) recover from GEM's negative effects.
- The treatment also affected cell cycle phases differently in cancer cells and HDFs, with PRO alone increasing reactive oxygen species (ROS), suggesting specific combinations of PRO/GEM can target cancer cells while protecting normal cells.
