Publications by authors named "Benedetta Girardi"
ChemMedChem
February 2022
Article Synopsis
- * The research focused on enhancing a known galectin-8 ligand by modifying its structure, resulting in improved affinity with a K value of 12 µM.
- * The modified compound shows reasonable selectivity for galectin-8 compared to other galectins, making it a promising candidate for developing new ligands to study the protein's role in cellular and in-vivo contexts.
ChemMedChem
September 2020
Article Synopsis
- * Targeting Siglec-8 can lead to cell death in eosinophils and reduce the activity of mast cells, making it a potential treatment method for related diseases.
- * Researchers have developed a high-affinity mimic of a specific Siglec-8 ligand, which binds better than before, enhancing its ability to engage with the target protein effectively.
