Predictors and prognosis of elderly hip fracture patients with perioperative atrial fibrillation: a nested case-control study.

Background: A scarcity of data exists concerning atrial fibrillation (AF) during the perioperative stage of non-cardiothoracic surgery, particularly orthopedic surgery. In addition, given the frequency and significant impact of AF in the perioperative period, therefore our aim was to identify prognosis and predictors of elderly hip fracture patients with perioperative AF.

Methods: An examination of hip fracture patients at the Third Hospital of Hebei Medical University, who had been hospitalized from January 2018 to October 2020 in succession, was conducted retrospectively.

Efficacy of PDD-guided tumor excision combined with photodynamic therapy in cutaneous squamous cell carcinoma.

Background: Cutaneous squamous cell carcinoma (cSCC) is an aggressive tumor with unclear margins. Photodynamic diagnosis (PDD) enables the differentiation of tumor tissue from normal tissue via visible fluorescence. Photodynamic therapy (PDT) is widely used in the treatment of non-melanoma skin tumors.

Efficient Expression and Activity Optimization of Manganese Peroxidase for the Simultaneous Degradation of Aflatoxins AFB, AFB, AFG, and AFG.

Aflatoxins (AFs), notorious mycotoxins that pose significant risks to human and animal health, make biodegradation extremely crucial as they offer a promising approach to managing and reducing their harmful impacts. In this study, we identified a manganese peroxidase from (Mnp) through protein similarity analysis, which has the capability to degrade four AFs (AFB, AFB, AFG, and AFG) simultaneously. The gene encoding this enzyme was subject to codon optimization, followed by cold shock induction expression using the pColdII vector, leading to the soluble expression of manganese peroxidase (Mnp) in .

Identification model of mine water inrush source based on XGBoost and SHAP.

This study focuses on the construction and interpretation of a mine water inrush source identification model to enhance the precision and credibility of the model. For water inrush source identification and feature analysis, a novel method combining XGBoost and SHAP is suggested. The model uses Ca, Mg, K + Na, HCO, Cl, SO, Hardness, and pH as discriminators, and the key parameters in the XGBoost model are optimized by introducing the improved sparrow search algorithm.

Study of the spatial strength distribution patterns and microstructure characteristics of ultra-fine tailings cemented paste backfill.

In this study, the spatial distribution of the mechanical strength of ultra-fine tailings cemented paste backfill (UCPB) in underground stopes was examined, and the micro-mechanism responsible for differences in spatial strength performance via changes in particle deposition was elucidated. To better understand this phenomenon, we constructed a similar backfilling stope model using the ultra-fine tailings of a gold mine. We manufactured specimens at different spatial locations and conducted a novel series of tests, including uniaxial compressive strength, shear strength, and conventional triaxial tests, to obtain the strength parameters in different spatial distributions.

Many-body van der Waals interactions in multilayer structures studied by atomic force microscopy.

Van der Waals interaction in multilayer structures was predicted to be of many-body character, almost in parallel with the establishment of Lifshitz theory. However, the diminishing interaction between layers separated by a finite-thickness intermediate layer prevents experimental verification of the many-body nature. Here we verify the substrate contribution at the adhesion between the atomic force microscopy tip and the supported graphene, by taking advantage of the atomic-scale proximity of two objects separated by graphene.

HPV genotypes in invasive cervical cancer: prevalence, risk attribution, and optimized vaccine strategies in western China.

Background: Understanding the HPV genotype distribution in invasive cervical cancer (ICC) is essential for vaccine optimization. This study presents a comprehensive analysis of HPV genotypes in ICC tissues from patients in western China, with the aim of informing regional vaccine policy and prevention strategies.

Methods: DNA was extracted from 1,908 paraffin-embedded ICC samples, and 23 HPV genotypes were detected via PCR and reverse dot hybridization gene chip assays.

[The Prognostic Predictive Value of mutation Variant Allele Frequency in Diffuse Large B-Cell Lymphoma].

Objective: To explore the effect of mutation variant allele frequency(VAF) on the prognosis of diffuse large B-cell lymphoma(DLBCL) patients.

Methods: This study included 155 patients with DLBCL who were first diagnosed in the People's Hospital of Xinjiang Uygur Autonomous Region from March 2009 to March 2022. Complete clinical data and paraffin-embedded tumor tissue samples were obtained, and DNA was extracted from tumor tissues.

The de novo synthesis of GABA and its gene regulatory function control hepatocellular carcinoma metastasis.

The neurotransmitter gamma-aminobutyric acid (GABA) has been thought to be involved in the development of some types of cancer. Yet, the de novo synthesis of GABA and how it functions in hepatocellular carcinoma (HCC) remain unclear. Here, we report that SLC6A12 acts as a transporter of GABA, and that aldehyde dehydrogenase 9 family member A1 (ALDH9A1), not glutamate decarboxylase 1 (GAD1), generates GABA in human HCC.

Temporal relationship between symptom cluster and quality of life in rectal cancer patients after laparoscopic anus-preserving surgery.

Although it is generally recognized that symptom clusters and quality of life are related, major ambiguity arises from the difficulty in determining their causal relationship. The present study aimed to investigate longitudinal causal relationships between symptom clusters and quality of life. 128 patients with rectal cancer from Nanchong City, Sichuan Province who underwent laparoscopic anus-preserving surgery completed 4 follow-up visits, and the survey time point are 2 weeks after surgery (T1), 1 month after surgery (T2), 3 months after surgery (T3), and 6 months after surgery (T4).

Balanced diets are associated with a lower risk of type 2 diabetes than plant-based diets.

Background & Aims: Plant-based diets benefit human health, while the deficient in some nutrients limits its application. We aimed to examine whether balanced diets could be better in reducing diabetes risk than plant-based diets.

Methods: In cross-sectional analysis of Environment-Inflammation-Metabolic-Diseases Study (EIMDS), we used a questionnaire to investigate the habit of balanced and plant-based diets.

The Role of Sex Hormones and Sex Hormone-binding Globulin in Functional Gatrointestinal Disorders: A Bidirectional Two-sample Mendelian Randomization Study.

Background And Aims: Sex hormones and sex hormone-binding globulin (SHBG) have been confirmed to involve in the pathophysiology of functional gastrointestinal disorders (FGIDs), including irritable bowel syndrome (IBS) and functional dyspepsia (FD). However, causal associations have not yet been investigated. Utilizing data from Genome-wide association studies, we conducted bidirectional two-sample mendelian randomization (MR) analyses to assess the causal relationships between sex hormones, SHBG and FGIDs.

Combined analysis of transcriptomics and metabolomics showed that SNAC4 and SNAC9 are negative regulators of the resistance to Botrytis cinerea in tomato.

NAC (NAM, ATAF1/2 and CUC2) is a transcription factor which contributes to the response for both biotic and abiotic stresses. In this study, the regulatory effects and potential mechanisms of SNAC4/9 on resistance to Botrytis cinerea (B. cinerea) were investigated by the differences in physiological and biochemical indices as well as transcriptional and metabolic profiles between SNAC4/9 overexpressed (OE-SNAC4/9) and wild-type (WT) tomato fruit inoculated with B.

Arbitrary Optics for Gaussian Splatting Using Space Warping.

Due to recent advances in 3D reconstruction from RGB images, it is now possible to create photorealistic representations of real-world scenes that only require minutes to be reconstructed and can be rendered in real time. In particular, 3D Gaussian splatting shows promising results, outperforming preceding reconstruction methods while simultaneously reducing the overall computational requirements. The main success of 3D Gaussian splatting relies on the efficient use of a differentiable rasterizer to render the Gaussian scene representation.

Polydopamine-functionalized capsules: From design to applications.

In recent years, polydopamine (PDA)-functionalized capsules have garnered significant interest from researchers in the field of materials, owing to its remarkable properties of adhesion, biocompatibility, photothermal conversion capabilities, chemical reactivity, and so on. At present, numerous studies have reported various structures and morphologies of PDA-functionalized capsules fabricated via diverse strategies, that have found applications across a broad spectrum of disciplines. However, there are few comprehensive and systematic reviews focusing on various preparation strategies of PDA-functionalized capsules with various structures.

A machine learning model for predicting abnormal liver function induced by a Chinese herbal medicine preparation (Zhengqing Fengtongning) in patients with rheumatoid arthritis based on real-world study.

Objective: Rheumatoid arthritis (RA) is a systemic autoimmune disease that affects the small joints of the whole body and degrades the patients' quality of life. Zhengqing Fengtongning (ZF) is a traditional Chinese medicine preparation used to treat RA. ZF may cause liver injury.

Evidence of sewage discharge on the coalescence mechanism of aquatic microbial communities during high amplitude hydrological periods.

Microbial community coalescence is a ubiquitous ecological process in various ecosystems. However, limited research has addressed the effects of the coalescence on microbial ecological processes and network structure, particularly in the context of sewage discharge during high amplitude hydrological periods. Employing 16S rRNA sequencing and species source tracking analysis, we investigated the coalescence pattern of bacterioplankton in the Chishui river and sewage across various hydrological periods.

Deficits in emotional cognition among individuals with conduct disorder: theoretical perspectives.

Conduct disorder refers to a persistent and repetitive pattern of problematic behavior, and is usually accompanied by deficits in cognitive processing of emotional stimuli. Behavioral and physiological correlates of these deficits have been the subject of sufficiently many investigations. Meanwhile, several theories concerning conduct disorder have been developed.

Clinical Insights into Neurosyphilis Patients with Leptomeningeal Enhancement of Spinal Cord.

Background And Objectives: This study aims to report the clinical, biological, and imaging features of cross-sectional study of neurosyphilis patients with leptomeningeal enhancement of spinal cord. Here, 51 neurosyphilis patients with leptomeningeal enhancement of spinal cord positivity are described, offering a promise in terms of early diagnosis, thereby enabling timely detection and treatment.

Methods: We retrospectively included all neurosyphilis patients enrolled in this study from December 2019 to January 2024.

Towards green, scalable peptide synthesis: leveraging DEG-crosslinked polystyrene resins to overcome hydrophobicity challenges.

Diethylene glycol dimethacrylate (DEG)-crosslinked polystyrene (PS) resin offers a promising alternative to traditional divinyl benzene (DVB)-PS resin for solid-phase peptide synthesis (SPPS), particularly for challenging sequences with hydrophobic or bulky amino acids. DEG-PS resin's reduced hydrophobicity and enhanced flexibility improve synthesis efficiency, yielding peptides up to 28 residues with higher purities and yields compared to DVB-PS. In various syntheses, DEG-PS outperformed DVB-PS resin, with higher purities and yields for challenging peptides such as ABC analogue (73.

Atezolizumab, bevacizumab, pemetrexed and platinum for EGFR-mutant NSCLC patients after EGFR TKI failure: A phase II study with immune cell profile analysis.

Background: Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) remains a significant hurdle for patients with EGFR-mutated non-small cell lung cancer (NSCLC), particularly those lacking the EGFR. IMpower 150 study demonstrated promising efficacy for a combination of immune-chemotherapy and bevacizumab in patients with EGFR-mutated NSCLC.

Methods: This open-label, single-arm, phase II trial evaluated the efficacy and immune cell profile of the modified regimen combining atezolizumab, bevacizumab (7.

Observation of quantum oscillations near the Mott-Ioffe-Regel limit in CaAs.

The Mott-Ioffe-Regel limit sets the lower bound of the carrier mean free path for coherent quasiparticle transport. Metallicity beyond this limit is of great interest because it is often closely related to quantum criticality and unconventional superconductivity. Progress along this direction mainly focuses on the strange-metal behaviors originating from the evolution of the quasiparticle scattering rate, such as linear-in-temperature resistivity, while the quasiparticle coherence phenomena in this regime are much less explored due to the short mean free path at the diffusive bound.

Effects of pH shift and D-galactose on network structure of glycinin gel and diffusion behavior of non-network proteins.

To reduce the content of non-network proteins in protein-based gels, a synergistic approach involving pH shift and D-galactose (DG) was developed herein to obtain elastic gels with dense networks. The results revealed that the combined effect of pH shift and DG promoted the formation of additional disulfide bonds and chemical bonds between molecules, resulting in a denser, and highly elastic gel network, which immobilized more aggregates, leading to a significant reduction in non-network protein content, and enhancing the functional properties of the gel. Moreover, non-network proteins primarily consisted of subunit A (mostly Glu and Asp), while the subunit B was the primary polypeptide forming the gel network.

Associations between housing quality and sarcopenia among older adults: evidence from China and India.

Objectives: Housing is an important social determinant of health. However, limited studies have focused on the relationship between housing quality and sarcopenia, especially in low- and middle-income countries. This study aims to examine the association between housing quality and sarcopenia in older adults in China and India.