Genotype-phenotype correlation in Moroccan patients with primary congenital glaucoma.

Purpose: To investigate the genotype-phenotype correlation in a large cohort of Moroccan primary congenital glaucoma (PCG) in which CYP1B1 mutation spectrum was recently reported by our group.

Methods: This study included 94 patients from 84 unrelated Moroccan PCG families with or without CYP1B1 mutations. Clinical features, severity of the phenotype, and prognosis were mainly compared in patients with no CYP1B1 mutations, double CYP1B1 null alleles or nondouble null but other CYP1B1 mutations; most of them were hypomorphic mutations.

[Orbital schwannoma: clinical, imaging and surgical features].

Introduction: Schwannoma, or peripheral glioma, is a rare tumor of the orbit (1% of orbital tumors). Its diagnosis remains difficult and can be established only by histological analysis. We discuss through this case report the clinical, radiological and surgical features of this tumor.

[Marcus Gunn Syndrome. Study of 3 rare cases].

Purpose: reporting three rare cases of Marcus Gunn Syndrome and analyzing the clinical features of this entity.

Methods: Case reports of three patients with a Marcus Gunn Syndrome, treated at the Ophthalmology B CHU service Rabat - Morocco.

Results: Our patients are two boys aged 1 and 2 years old, and a 31 year old woman with a Marcus Gunn Syndrome.

Screening of CYP1B1 and MYOC in Moroccan families with primary congenital glaucoma: three novel mutations in CYP1B1.

Purpose: To investigate the contribution of cytochrome P4501B1 (CYP1B1) and myocillin (MYOC) mutations to primary congenital glaucoma (PCG) in Moroccan families.

Methods: This study included 90 unrelated families with PCG and 100 normal control individuals. Two previously reported CYP1B1 mutations (g.

[Devic's neuro-optic myelitis and pregnancy].

Introduction: Devic's neuromyelitis optica associates optical neuritis that is either unilateral or bilateral and acute transversal myelopathy. This disease seldom occurs and is rarely associated with pregnancy.

Observation: We report the case of a young 20-year-old woman who was 8 weeks pregnant.

[Macular serous detachment revealing acute lymphoblastic leukemia].

Background: Leukemias are a group of malignant diseases caused by immature hematopoietic cells proliferating in the blood marrow. Some manifestations result from ocular-orbital involvement, which usually occurs through the central nervous system. Other manifestations stem from vasculopathy and/or hemorheologic disorders (anemia, thrombocytopenia, hyperviscosity).

[Visual prognosis factors in congenital cataract].

Purpose: Study of different factors which can change the visual prognosis in congenital cataract.

Methods: One hundred seventy eyes of 100 children with congenital cataract are operated by extracapsular cataract extraction with limbic incision. Posterior rhexis and anterior vitrectomy were associated in children under 2 years.

[Value of ultrasonography in persistent hyperplastic primary vitreous body. Apropos of 4 cases].

The authors report 4 patients with complicated persistent hyperplastic primary vitreous. The complications observed are cataract (2 eyes) and retinal detachment (2 eyes). The affection is bilateral in two cases and unilateral in the two other cases.