Comparative post-therapeutic dosimetry between 2D planar-based and hybrid-based methods for personalized Lu-177 treatment.

Purpose: This study aims to compare the calculated absorbed dose in target organs and tumors obtained using the different imaging protocols and the calculation methodologies implemented by HERMES HybridViewer dosimetry software for Lu-PSMA I&T and Lu-DOTATATE therapy.

Methods: Multiple time-point whole-body planar images and one SPECT/CT image were acquired from 18 patients including Lu-PSMA I&T (13 patients) and Lu-DOTATATE treatment (5 patients) after administration of 3.80-8.

Bone turnover prediction in patients with chronic kidney disease (CKD) undergoing hemodialysis using shortened dynamic F-NaF PET/CT K-Patlak.

This study investigated whether K-Patlak derived from a shortened scan time for dynamic F-NaF PET/CT in chronic kidney disease (CKD) patients undergoing hemodialysis can provide predictive accuracy comparable to that obtained from a longer scan. Twenty-seven patients on chronic hemodialysis, involving a total of 42 scans between December 2021 and August 2023 were recruited. Dynamic F-NaF PET/CT scans, lasting 60-90 min, were immediately acquired post-injection, covering the mid-twelfth thoracic vertebra to the pelvis region.