Phytochemical on-line screening and study of : antioxidant activity, DFT, MD simulation, ADME/T analysis, and xanthine oxidase binding.

Seven components from the methanol extract of the aerial part of the endemic species were isolated and identified for the first time. Investigating this species and its separated components chemical make-up and radical scavenging capacity, was the main goal. Using an online HPLC-ABTS˙ test, ORAC, and TEAC assays, the free radical scavenging capacity of the ethyl acetate extract was assessed.

Spach. protects against acetaminophen-induced liver failure via preserving the glutathione redox system, reducing inflammatory response, and inhibiting hepatocyte death in rats.

Objectives: The current study was conducted to assess the protective mechanisms of BuOH fraction from the aerial part of (BEGC) on APAP-induced liver injury compared to necrostatine-1 (Nec-1).

Materials And Methods: A model of APAP-induced hepatotoxicity was created in male rats by injecting a single dose; 1000 mg/kg APAP, the protective effect was performed with (200 mg/kg; 10 days) BEGC compared to Nec-1, (1.8 mg/kg).

Flavonoids-rich Fraction Alleviates Liver Injury in Mice Overconsumed Fructose Model.

Background: Non-alcoholic Fatty liver disease (NAFLD) is becoming a major global health burden in the world. is an edible plant growing wild in the North of Algeria. Its potential as a source of health-promoting compounds is still underexplored.

A new isoflavonoid derivative, evaluation of the antioxidant capacity and phenolic content of DC.

The phytochemical investigation of both chloroform and ethyl acetate extracts of DC from an Algerian endemic plant led to the isolation of a new isoflavonoid Aspalathoidin compound () and nine known compounds (laburnetin, isokaempferide, retamasin B, ephedrodin, sakuretin, isoprunetin, genistein -7--β-glucoside, derrone-4'--methyl ether and eriodictyol-7,3'-dimethylether). Twelve phenolic compounds were identified in ethyl acetate and -butanol extracts through a qualitative investigation of phenolic compounds using HPLC. Finally, both extracts were estimated for their phenolic and flavonoid contents as well as the evaluation of their antioxidant activity using five different assays DPPH, CUPRAC, ABTS, GOR and the sun protection factor SPF was determined as an index of the photoprotective capacity of the DC extracts.

Evaluation of anti-inflammatory, diuretic and oral glucose tolerance activities of phenolic compound-rich fractions of Hammada articulata in Albino Wistar rats.

Hammada articulata is a plant widely used by the locals of the Algerian Sahara for multiple medicinal purposes. However, little was known about its chemical composition and the mechanisms of its bioactivity. For this purpose, the derived extracts [chloroform (CHCl), ethyl acetate (EtOAc) and n-butanol (n-BuOH)] of the 80% ethanol extract of its aerial parts, were evaluated for their anti-inflammatory, diuretic, and anti-hyperglycemic activities in vivo.

The preventive effects of Ball. extract against oxidative stress induced by cisplatin in mice brains: and studies.

Since antiquity, species have been used in folk medicine to treat several diseases owing to their potential biological activities that distinguish this genus such as antioxidant, anticancer, and anti-inflammatory effect. The current study aimed to investigate the possible neuroprotective effects of the -butanol extract of (BECM) against cisplatin (CP) induced neurotoxicity in mice. BECM's potential neuroprotective properties were studied and models.

Phytochemical investigation of and evaluation of the antioxidant activity.

(L.) Cass. ex Maire, syn.

Neuroinflammation and Behavioral Deficit in Rotenone-Induced Neurotoxicity in Rats and the Possible Effects of Butanolic Extract of .

Background: Many studies have used rotenone (ROT) to create an experimental animal model of Parkinson's disease (PD) because of its ability to induce similar behavioral and motor deficits. PD is the most common age-related motoric neurodegenerative disorder. Neuroinflammation and apoptosis play an important role in the pathogenesis of this disease.

First report on phytochemical investigation, antioxidant and antidiabetic activities of .

A new flavonoid, 5,7,2',4',5'-pentahydroxyflavone 3--β-D-galactopyranoside ( and twelve known derivatives: an aryltetralin-lignan (, seven flavonoids (, , ) and four phenolic acids (, , ) have been isolated from the aerial parts of Pomel. ( family) an endemic species to the septentrional Sahara that is being studied for the first time. Structure elucidation of the isolated compounds was established by means of spectroscopic methods especially NMR and Mass Spectrometry.

Bio-guided isolation of leishmanicidal and trypanocidal constituents from Pituranthos battandieri aerial parts.

Protozoan pathogens that cause neglected tropical diseases are a major public health concern in tropical and developing countries. In the course of our ongoing search for new lead compounds as potential antiprotozoal agents, this study aims to perform a bio-guided fractionation of Pituranthos battandieri, using an in vitro assay against Leishmania amazonensis and Trypanosoma cruzi. Two known polyacetylenes, (-)-panaxydiol (1) and (-)-falcarindiol (2) were identified from the ethanolic extract of the aerial parts of P.

Antioxidant, Anti-Inflammatory and Cytotoxic Properties of Lamk var. [Bonnet] M].

Background: In Algerian traditional medicine, Centaurea species are well known in traditherapy. Centaurea africana has been used in folk medicine for the treatment of several inflammatory disorders.

Objective: This study aims to examine the antioxidant, anti-inflammatory and anti-proliferative potential of both n-Butanol (BECA) and ethyl acetate (EAECA) extracts of Centaurea africana.

Chemical Constituents, Antioxidant, Anticholinesterase and Antiproliferative Effects of Algerian Pistacia atlantica Desf. Extracts.

Background: Pistacia atlantica Desf. (Anacardiaceae) has various applications for dietetic and medicinal purposes.

Objective: The aim of the present study was to evaluate antioxidant, antiproliferative and anticholinesterase activities of different extracts from leaf and stem of Pistacia atlantica Desf.

Characterization of ethyl acetate and n-butanol extracts of Cymbopogon schoenanthus and Helianthemum lippii and their effect on the smooth muscle of the rat distal colon.

Ethnopharmacology Relevance: Cymbopogon schoenanthus (C. schoenanthus) and Helianthemum lippii (H. lippii) are Saharan species found in the South West of Algeria, in the region of Bechar.

Essential oil constituents of L. and L. (Cupressaceae) growing in Aures region of Algeria.

The purpose of this study was to determine the chemical composition of essential oils from the aerial parts of two species belonging to the Cupressaceae family growing in the Aures region of Algeria and The analysis by GC-MS and GC-FID techniques showed the presence of 38 compounds in oil where the major constituents were manoyl oxide (23.5%), pentadecan-2-enone 6Z (12.6%), abietatriene (8.

Apigenin rich- (de Girard) Kuntze promotes apoptosis in HCT116 cancer cells.

The pro-apoptotic property of -BuOH extract of (BEL) and its major isolated components [apigenin (APG1) and apigenin7-O-β-D-(6''-methylglucuronide) (APG2)] were tested. The anti-proliferative IC of BEL and APG1 was quantified as 7.60 µg/mL and 25.

In vitro antioxidant, DNA-damaged protection and antiproliferative activities of ethyl acetate and n-butanol extracts of Centaurea sphaerocephalaL.

This study aimed to evaluate the in vitro antiproliferative and inhibition of oxidative DNA-damage activities of n-butanol (n-BuOH) extract of Centaurea sphaerocephala. The in vitro antioxidant activity of the ethyl acetate (EtOAc) and the n-BuOH extracts of this plant were also assayed. To investigate the antioxidant potential, extracts were tested for their capacity to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH·) and to inhibit lipid peroxidation using the TBARs method.

New sesquiterpenes from .

(Forsk) Less. is a Saharan medicinal plant of Asteraceae family. A new acyclic sesquiterpene [7,12-dihydroxy-6,7-dihydro-5,(6) -dehydronerolidol ()] and sesquiterpene germacranolide lactone derivatives [9β-hydroxy-11β,13-dihydroparthenolide-9-O-β-D-glucopyranoside () and 9α-hydroxy-11β,13-dihydroparthenolide-9-O-β-D-glucopyranoside ()] along with eight known compounds were isolated from polar extracts of aerial parts.

Hepatoprotective effects of the n-butanol extract from Perralderia coronopifolia Coss. against PCP-induced toxicity in Wistar albino rats.

In the present study, in vivo antioxidant properties of the n-butanol extract obtained from aerial parts of Perralderia coronopifolia were investigated in term of its hepatoprotective effect of female Wistar albino rats (n, 36; average age, 48 ± 5 days; weighing 150 ± 18 g) against PCP (pentachlorphenol)-induced toxicity. PCP (20 mg/kg b.w.

Halimium halimifolium: From the Chemical and Functional Characterization to a Nutraceutical Ingredient Design.

(Hh) is a shrub used in Algerian folk medicine to treat gastrointestinal pain. An UHPLC-PDA-ESI/MS method was developed to identify the metabolic profile of the traditionally used infusion (Hh-A) from the aerial parts. The structures of flavanols were confirmed by NMR analysis after the isolation procedure from a hydrohalcolic extract (Hh-B) that also allowed for the identification of phenolic acids, an aryl butanol glucoside, and different derivatives of quercetin, myricetin, and kaempferol.

Chemical constituents and HRESI-MS analysis of an Algerian endemic plant - batt. - extracts and their antioxidant activity.

This is the first report on the phytochemistry and antioxidant activity of ethyl acetate and - butanol extracts from an Algerian endemic plant Batt. (Scrophulariaceae). Both extracts were subjected to a phytochemical study by semi-preparative HPLC, which led to the isolation and identification of nine compounds: methyl linolenate (1), methyl linoleate (2), Phytol-1(3), Martynoside (4), Isomartynoside (5), -martynoside (6), Ilwensisaponin C (7), Ilwensisaponin B (8), Ilwensisaponin A (9).

Polyphenolic content and bioactivities of L. (Rosaceae).

Solid-Liquid Extraction (SLE) using solvent of different polarities (CHCl, EtOAc, and -BuOH) has been applied to leaves and fruits from ( L.), a deciduous shrub with an expected rich phytochemical profile. The total polyphenols content and the radical scavenging activity of each extract were evaluated.

Anti-inflammatory and Antioxidant Effects of on Paracetamol-induced Hepatitis in Rats.

Background: Herbal medicines have been used in the treatment of liver diseases for a long time. The current study was elaborated to evaluate in vitro and in vivo antioxidant and anti-inflammatory effects of Lotus corniculatus (L. corniculatus) butanolic extract.

Chemical composition, antiparasitic, antimicrobial and antioxidant activities of Desf.

This study was performed on the derived fractions [chloroform (FT-C), ethyl acetate (FT-E) and -butanol (FT-B)] of the 70% ethanol extract prepared from , endemic to North Africa. The fractions showed high total phenolic and flavonoid contents particularly FT-E. These results agreed with their antioxidant effects.

Amino acid-sesquiterpene lactone conjugates from the aerial parts of Centaurea pungens and evaluation of their antimicrobial activity.

Two new amino acid-sesquiterpene lactone conjugates, named centaureolide A (1) and centaureolide B (2) along with a germacrane derivative (3), five flavonoids (4-8) and one quinic acid derivative (9) have been isolated from the aerial parts of Centaurea pungens (Asteraceae). Their structures were established by a combination of one- and two-dimensional NMR techniques, and mass spectrometry. The never reported sesquiterpene lactones have been determined as germacrane derivatives (1 and 2) characterized by the unusual occurrence of a proline moiety.

On-line screening and identification of polyphenolic antioxidant compounds of .

Schweinf. & Muschl. is an endemic plant from northern Sahara used in folk medicine.