Publications by authors named "Benanti G"
Article Synopsis
- Systemic lupus erythematosus (SLE) leads to immune dysfunction and increased infection susceptibility, often resulting in infection-associated flares (IAFs) that can resolve alongside infections.
- In a study of 2,039 visits, researchers identified 134 flares (17% yearly deterioration of lupus low disease activity state [LLDAS]), with 38 classified as IAFs primarily linked to bacterial and herpesvirus infections.
- IAFs showed similar or greater severity in symptoms compared to other flares, with distinct characteristics such as lower anti-DNA antibody levels in viral IAFs, indicating the need for further research to explore these differences and improve treatment approaches.
Impact of asthma on severe food-induced allergic reactions: a systematic review and meta-analysis.
Eur Ann Allergy Clin Immunol
June 2024
Food allergy can range from mild to severe, life-threatening reactions with various symptoms and organ involvement. The impact of asthma on severe food-induced allergic reactions is not completely understood. In the hypothesis that asthma increases the risk of severe food-induced allergic reactions, the aim of this study is to compare the incidence of severe food-induced allergic reactions in patients with history of asthma compared with patients without history of asthma.
View Article and Find Full Text PDFDrug development and novel therapeutics to ensure a personalized approach in the treatment of systemic sclerosis.
Expert Rev Clin Immunol
November 2023
Introduction: Systemic sclerosis (SSc) is a systemic disease encompassing autoimmunity, vasculopathy, and fibrosis. SSc is still burdened by high mortality and morbidity rates. Recent advances in understanding the pathogenesis of SSc have identified novel potential therapeutic targets.
View Article and Find Full Text PDFBasophil activation test (BAT) can tackle multiple mechanisms underlying acute and delayed hypersensitivity to drugs and vaccines and might complement conventional allergy diagnostics but its role in anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine-related hypersensitivity is ill-defined. Therefore, 89 patients with possible hypersensitivity (56 % with delayed mucocutaneous manifestations) to anti-SARS-CoV-2 vaccines were tested with BAT for Macrogol 3350, DMG-PEG 2000, PEG 20000, polysorbate-80 and trometamol and compared to 156 subjects undergoing pre-vaccine BAT. A positive BAT was associated with delayed reaction onset (p = 0.
View Article and Find Full Text PDFStudy Objective: Severe coronavirus disease 2019 (COVID-19) increases the risk of thrombotic complications with unfractionated heparin (UFH) as a commonly used agent in managing venous thromboembolism (VTE). The optimal anticoagulation intensity and monitoring parameters in intensive care unit (ICU) COVID-19 patients remains controversial. The primary study aim was to evaluate the relationship between anti-Xa and thromboelastography (TEG) reaction (R) time in patients with severe COVID-19 receiving therapeutic UFH infusions.
View Article and Find Full Text PDFAnti-Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) vaccination is the world's most important strategy for stopping the pandemic. Vaccination challenges the body's immune response and can be complicated by hypersensitivity reactions. The autonomic nervous system can modulate the inflammatory immune response, therefore constituting a potential marker to characterize individuals at high risk of hypersensitivity reactions.
View Article and Find Full Text PDFDrug reaction with eosinophilia and systemic symptoms (DRESS) is a heterogeneous, multiorgan and potentially life-threatening drug-hypersensitivity reaction (DHR) that occurs several days or weeks after drug initiation or discontinuation. DHRs constitute an emerging issue for public health, due to population aging, growing multi-organ morbidity, and subsequent enhanced drug prescriptions. DRESS has more consistently been associated with anticonvulsants, allopurinol and antibiotics, such as sulphonamides and vancomycin, although new drugs are increasingly reported as culprit agents.
View Article and Find Full Text PDFAntimicrobial Stewardship Techniques for Critically Ill Patients with Pneumonia.
Antibiotics (Basel)
February 2023
Pneumonia is common in the intensive care unit (ICU), infecting 27% of all critically ill patients. Given the high prevalence of this disease state in the ICU, optimizing antimicrobial therapy while minimizing toxicities is of utmost importance. Inappropriate antimicrobial use can increase the risk of antimicrobial resistance, infection, allergic reaction, and other complications from antimicrobial use (e.
View Article and Find Full Text PDFStudy Objective: Thromboelastography (TEG) offers a more dynamic assessment of hemostasis over activated partial thromboplastin time (aPTT). However, the clinical utility of TEG in monitoring bivalirudin during extracorporeal membrane oxygenation (ECMO) remains unknown. The purpose of this study was to evaluate the correlation between aPTT and TEG in adult ECMO patients anticoagulated with bivalirudin.
View Article and Find Full Text PDFBackground: The clinical utility of methicillin-resistant (MRSA) nasal screening appears promising for antimicrobial stewardship programs. However, a paucity of data remains on the diagnostic performance of culture-based MRSA screen in the intensive care unit (ICU) for pneumonia and bacteremia.
Objective: The objective of this study was to compare the predictive value of culture-based MRSA nasal screening for pneumonia and bacteremia in ICU and general ward patients.
Severe drug allergy affects patient hesitancy to new treatments, posing unprecedented challenges to anti-SARS-CoV-2 vaccination campaigns. We aimed to analyze the psychological profile of vaccinees with a history of severe allergy in comparison to subjects with a milder allergy history. Patients attending a dedicated vaccination setting were administered an anonymized questionnaire including clinical data and the State-Trait Anxiety Inventory (STAI) scale (score range 20−80).
View Article and Find Full Text PDFArticle Synopsis
- The study analyzes and compares the disease characteristics and treatment approaches for Takayasu arteritis (TAK) in patients from Italy and India, focusing on imaging methods and immunosuppressive therapies.
- A total of 318 patients were examined, revealing that ultrasound was primarily used in Italy while CT angiography was favored in India; corticosteroids were more commonly prescribed and for longer in Italy compared to India.
- The findings suggest significant differences in treatment modalities, likely influenced by socio-economic factors, highlighting the need for tailored treatment guidelines for TAK based on regional practices.
Systemic sclerosis (SSc) is a rare connective tissue disease characterised by immune dysfunction, vascular damage and fibrosis affecting the skin and multiple internal organs. The clinical spectrum of SSc is wide and its manifestations may lead to severe morbidity and mortality, in addition to a great impact on patients' quality of life. Due to the multifaceted clinical manifestations of SSc, its management requires a combined expertise of different medical specialists to guarantee an adequate disease control and prevent organ complications.
View Article and Find Full Text PDFInfections with extended-spectrum-β-lactamase (ESBL)-producing are common in patients with hematologic malignancy. The utility of cefepime and piperacillin-tazobactam as empiric therapy for ESBL-producing bacteremia in patients with hematologic malignancy is largely unknown. We conducted a single-center, retrospective cohort review of 103 adult inpatients with leukemia and/or hematopoietic stem cell transplant (HCT) recipients with monomicrobial ESBL-producing bacteremia.
View Article and Find Full Text PDFDiabetes Outcomes: Comparison of Patient Assistance Programs to 340B Drug Pricing.
J Health Care Poor Underserved
April 2018
Background: Patient assistance programs (PAPs) or obtaining 340B drug pricing offers a means of providing medications at low cost. The purpose of this study was to determine whether primary care patients who receive insulin from PAPs have an improved change in A1C, compared to 340B patients.
Methods: This was a retrospective study of primary care patients who obtained insulin therapy through a PAP or 340B between June 1, 2012, and June 1, 2013.