Publications by authors named "Ben-Long Yang"
Article Synopsis
- A phase II trial was conducted to evaluate the efficacy and safety of a new neoadjuvant chemoimmunotherapy regimen combining chemotherapy with the PD-1 antibody toripalimab for early-stage triple-negative breast cancer (TNBC).
- The study included 70 female patients with stage II-III TNBC, who received a combination of standard chemotherapy and immunotherapy, with primary endpoints focusing on total and breast pathological complete response rates.
- Results showed that over half of the participants achieved tumor response, with some experiencing manageable side effects, indicating that this treatment combination is promising and worthy of further research.
Background: Targeted axillary dissection (TAD) includes biopsy of clipped lymph node and sentinel lymph nodes. However, clinical evidence regarding clinical feasibility and oncological safety of non-radioactive TAD in a real-world cohort remains limited.
Methods: In this prospective registry study, patients routinely underwent clip insertion into biopsy-confirmed lymph node.
The aim of this study was to investigate the trends of axillary lymph node evaluation in ductal carcinoma in situ (DCIS) patients treated with breast-conserving therapy (BCT) and to identify the clinicopathological predictors of axillary evaluation. DCIS patients treated with BCT in 2006-2015 at our institute were retrospectively included in the analysis. Patients were categorized into three groups: sentinel lymph node biopsy (SLNB), axillary lymph node dissection (ALND), and non-evaluation.
View Article and Find Full Text PDFObjectives: The current study aims to summarize breast anthropomorphic measurement features in Chinese patients with breast diseases and to investigate their potential correlations with demographic factors.
Materials And Methods: Fifteen breast anthropomorphic parameters of 605 Chinese female patients were collected prospectively. Breast ptosis status was scaled by two methods and breast volume was calculated according to a modified formula of BREAST-V.
The aim of the study was to review the surgical trends in breast cancer treatment in China over the past 15 years and to explore the possible factors related to the choice of surgical modality.The medical records of 18,502 patients with unilateral early stage breast cancer who underwent surgery from January 1999 to December 2013 at our institute were retrospectively reviewed. The utilization of different surgical modalities and the associated clinicopathological factors were analyzed.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to evaluate the current state of breast reconstruction in China, particularly after mastectomy for breast cancer, analyzing data from 951 reconstruction cases over 15 years.
- The results showed a shift towards prosthesis-based reconstruction, which became the most common method, alongside significant use of abdominal and latissimus dorsi flap techniques.
- Despite the increase in procedures, the overall rates of local-regional recurrence were low, indicating effective management and treatment outcomes for patients undergoing reconstruction.
The study of this study is to assess the current status and trend of the application of breast reconstruction in China.A retrospective review of all patients who had received surgical treatment for breast cancer in the Fudan University Shanghai Cancer Center between January 1999 and June 2014 was performed. The clinicopathological and epidemiological parameters and the follow-up information of each patient were collected.
View Article and Find Full Text PDFWe assessed the MSKCC nomogram performance in predicting SLN metastases in a Chinese breast cancer population. A new model (the SCH nomogram) was developed with clinically relevant variables and possible advantages. Data were collected from 1,545 patients who had a successful SLN biopsy between March 2005 and November 2011.
View Article and Find Full Text PDFBackground: Accurate intraoperative diagnosis of sentinel lymph node (SLN) metastases enables the selection of patients for axillary lymph node dissections during the same operation, reducing the need for a second operation. The present study aimed to prospectively compare the GeneSearch(TM) Breast Lymph Node (BLN) Assay with touch imprint cytology (TIC) for intraoperative evaluation of SLNs.
Methods: SLNs were sectioned in 1.
[Evaluation of intraoperative molecular assay in sentinel lymph node biopsy from breast cancer patients].
Zhonghua Bing Li Xue Za Zhi
November 2010
Objective: to evaluate the application of GeneSearch(TM) breast lymph node assay in intraoperative detection of metastases in sentinel lymph node (SLN) from breast cancer patients.
Methods: a total of 225 SLN from 88 patients was prospectively studied. Each SLN was cut into 2 mm slabs which were examined by intraoperative imprint cytology (IIC) first, followed by GeneSearch assay and post-operative serial sectioning.
Background: Accurate intraoperative diagnosis of sentinel lymph node (SLN) metastasis reduces the need for additional surgery in patients with involved nodes. The present study evaluates the clinical value of multiple cross-sectional touch imprint cytology (TIC) as an intraoperative assessment for the diagnosis of SLN metastasis.
Methods: This study consisted of 366 patients with surgically harvested SLNs that were sliced along their long axis at 2.