[Absolute bioavailability of caffeic acid in rats and its intestinal absorption properties].

Objective: To investigate the absolute bioavailability of caffeic acid in rats and its intestinal absorption properties.

Method: The absolute bioavailability (Fabs) of caffeic acid was obtained after iv (2 mg x kg(-1)) or ig (10 mg x kg(-1)) administration to rats. The intestinal absorption of caffeic acid was explored by the recirculating vascularly perfused rat intestinal preparation.

Bioavailability of caffeic acid in rats and its absorption properties in the Caco-2 cell model.

Context: Caffeic acid (CA) is widely distributed in edible plants, and it is beneficial to human health by exerting various biological effects. The potential pharmacological activities of CA are dependent on its absorption in the gastrointestinal tract.

Objective: To investigate the bioavailability of CA in rats and its absorption properties in the Caco-2 cell model.