Publications by authors named "Ben Wieland"
Article Synopsis
- The unicellular parasite is responsible for giardiasis, a widespread gastrointestinal illness, and attaches to human intestines using a specialized organelle called the ventral disc.
- Researchers are investigating how this attachment occurs by measuring the detachment characteristics and adhesion forces of individual trophozoites on smooth surfaces using a technique called fluidic force microscopy.
- The study found that the adhesion forces of trophozoites exhibit unique patterns compared to other eukaryotic cells, indicating distinct mechanisms of attachment and detachment at the molecular level.
The adhesion of to abiotic surfaces is crucial for establishing device-related infections. With a high number of single-cell force spectroscopy measurements with genetically modified cells, this study provides insights into the adhesion process of the pathogen to abiotic surfaces of different wettability. Our results show that utilizes different cell wall molecules and interaction mechanisms when binding to hydrophobic and hydrophilic surfaces.
View Article and Find Full Text PDFStaphylococcus aureus is a common cause of catheter-related blood stream infections (CRBSI). The bacterium has the ability to form multilayered biofilms on implanted material, which usually requires the removal of the implanted medical device. A first major step of this biofilm formation is the initial adhesion of the bacterium to the artificial surface.
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