Publications by authors named "Ben Wankum"
Article Synopsis
- Innovative swallowable capsule technologies are being developed to enhance the oral delivery of biologics, addressing existing challenges.
- The swallowable capsule for intestinal drug delivery (SCIDD) can directly inject biological drugs into the small intestine wall, with tests showing a 70% success rate in animal models.
- A pilot study indicated that the SCIDD effectively facilitates the systemic uptake of adalimumab, suggesting its potential as a novel platform for oral delivery of systemic biologics.
Biological macromolecule drugs or biologics are not suited for commonly preferred oral delivery due to their intrinsic instability and physical, chemical, or immunological barriers to the gastrointestinal tract. Ingestible capsule robots (ICR) have become a versatile platform, including use for drug delivery applications for various gastrointestinal pathologies with future potential for systemic drug delivery. In this work, a tissue attachment mechanism (TAM) for a drug delivery ICR is introduced that can facilitate a non-invasive systemic delivery of unaltered biologics via direct injection through the insensate layers of the small intestine.
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