Key4OI Recommendations for Lung Function Guidance in Osteogenesis Imperfecta: Based on an Internationally Performed Comprehensive International Consortium for Health Outcomes Measurement Procedure.

Introduction: Pulmonary involvement in Osteogenesis Imperfecta (OI) can be severe but may be overlooked in milder cases. The Care4BrittleBones Foundation initiated this project to develop a set of global outcome measures focusing on respiratory-related issues in patients with OI. The objective was to reach an international consensus for a standardized set of outcomes and associated measuring instruments for the pulmonary care of individuals with OI.

A 79-Year-Old Woman With Advanced Lung Carcinoma and Bilateral Infiltrates.

A 79-year-old woman was admitted to the hospital for progressive dyspnea and severe hypoxemia, requiring oxygen supplementation. The dyspnea started approximately 3 to 4 weeks before presentation and was slowly progressive throughout the following weeks. Her medical history mentioned an adenocarcinoma with an epidermal growth factor receptor (EGFR) exon 19 deletion of the lung with metastases to the bones and brain for which treatment with osimertinib was started 14 months earlier.

Benefit of Concurrent Versus Sequential Chemoradiotherapy in Elderly Patients With Stage III Non-Small Cell Lung Cancer.

Introduction: Lung cancer is the largest cause of cancer-related deaths worldwide. Eighty-five percent of patients is diagnosed with non-small cell lung cancer (NSCLC). Almost a third of patients is aged over 75, but this group is poorly represented in clinical trials.

Digital versus analogue chest drainage system in patients with primary spontaneous pneumothorax: a randomized controlled trial.

Background: Patients with a primary spontaneous pneumothorax (PSP) who are treated with chest tube drainage are traditionally connected to an analogue chest drainage system, containing a water seal and using a visual method of monitoring air leakage. Electronic systems with continuous digital monitoring of air leakage provide better insight into actual air leakage and changes in leakage over time, which may lead to a shorter length of hospital stay.

Methods: We performed a randomized controlled trial comparing the digital with analogue system, with the aim of demonstrating that use of a digital drainage system in PSP leads to a shorter hospital stay.

[A man with a yellow coloured abnormality of his finger].

A 83-year-old man presented to the emergency department with signs of diabetes mellitus de novo and a yellow coloured abnormality of his left index finger. A plain radiograph of the left hand showed destruction of the proximal interphalangeal joint of digit II. With use of polarised light microscopy, the diagnosis 'gouty tophus' was established.

[Increased INR from concomitant use of acenocoumarol and capecitabine].

Background: A drug interaction between capecitabine and coumarin may result in an increased INR and bleeding complications.

Case Description: We describe an 80-year-old woman who presented with rectal bleeding and an increased INR due to the concomitant use of acenocoumarol and capecitabine for atrial fibrillation and metastatic cecal cancer, respectively.

Conclusion: In patients with a compelling indication for treatment with capecitabine and anticoagulant therapy, conversion to low-molecular weight heparin should be considered.

[A woman with skin lesions over her whole body].

A 37-year-old woman was admitted to the hospital because of generalized skin and mucosa lesions after she had started with carbamazepine. It appeared the lesions were part of Stevens-Johnson syndrome.

[A woman with painful, swollen legs].

A 72-year-old woman from the inlands of Surinam was admitted to the hospital because of chronic painful swelling of both legs, caused by filariasis.

[A progressive vomiting pre-schooler].

A 4-year-old boy with persistent vomiting had a peptic stenosis of the oesophagus.