Habitual physical activity facilitates stress-induced HSP72 induction in brain, peripheral, and immune tissues.

The mechanism(s) for how physically active organisms are resistant to many damaging effects of acute stressor exposure is unknown. Cellular induction of heat-shock proteins (e.g.

Acute stressor exposure facilitates innate immunity more in physically active than in sedentary rats.

Most previous stress-immune research focused on the immunosuppressive effects of stress on acquired immunity. More recently, it has become clear that acute stressor exposure can potentiate innate, as well as suppress acquired, immunity. For example, acute stress improves recovery from bacterial inflammation, a classic in vivo measure of innate immunity.