Added value of hybrid SPECT with CT imaging for predicting poor therapeutic efficacy of Sr in patients with bone metastasis.

To utilize single-photon emission computed tomography/computed tomography (SPECT/CT) scanning to investigate the usefulness of nerve root compression (NRC) and radioactive cold zone lesions (RCZLs) for predicting poor therapeutic efficacy of strontium-89 chloride (Sr-89) in patients with bone metastasis. Patients with bone metastatic neoplasms who had undergone baseline bone SPECT/CT scanning before Sr-89 therapy (148 MBq Sr-89 chloride by an intravenous injection for each patient) between July 2011 and July 2018 were included. Bone SPECT/CT images were assessed by two readers independently.

Early life stress affects limited regional brain activity in depression.

Early life stress (ELS) can alter brain function and increases the risk of major depressive disorder (MDD) in later life. This study investigated whether ELS contributes to differences in regional brain activity between MDD patients and healthy controls (HC), as measured by amplitude of low-frequency fluctuation (ALFF)/fractional (f)ALFF. Eighteen first-episode, treatment-naïve MDD patients and HC were assessed with the Childhood Trauma Questionnaire and resting-state functional magnetic resonance imaging.

Abnormal Baseline Brain Activity in Patients With Multiple Sclerosis With Simple Spinal Cord Involvement Detected by Resting-State Functional Magnetic Resonance Imaging.

Objective: The aim of this study was to assess the baseline brain activity in patients with multiple sclerosis with simple spinal cord involvement (MS-SSCI) using regional amplitude of low-frequency fluctuation (ALFF) and fractional ALFF (fALFF) as indexes.

Methods: Resting-state functional magnetic resonance imaging data were acquired from 24 patients with MS-SSCI and 24 healthy controls and were processed using the Resting-State Functional Magnetic Resonance Imaging Data Analysis Toolkit. The relationships between expanded disability status scale scores, abnormal baseline brain activity, and disease duration were explored.