Publications by authors named "Ben May"
Article Synopsis
- - Understanding how SARS-CoV-2 interacts with the host helps develop better treatments and public health responses, particularly targeting immune pathways linked to complement and coagulation systems.
- - A study found that individuals with a history of macular degeneration or coagulation disorders are at higher risk for severe COVID-19 outcomes, regardless of age, sex, or smoking history.
- - Genetic analysis identified specific variants linked to complement and coagulation functions, suggesting that these factors influence COVID-19 severity and highlighting the need for comprehensive research methods to assess immunity and disease susceptibility.
Article Synopsis
- - Understanding how SARS-CoV-2 interacts with the body can help develop better therapies and public health strategies, focusing on immune pathways related to complement and coagulation systems.
- - A study of over 11,000 patients found that pre-existing conditions related to these systems, like macular degeneration and coagulation disorders, increase risks of severe illness and death from COVID-19, independent of other factors like age or smoking.
- - Genetic analysis revealed specific genetic markers linked to immune response that could help predict COVID-19 outcomes, illustrating the importance of combining various research methods to understand disease susceptibility.
Major challenges to identifying genes that contribute to autism spectrum disorder (ASD) risk include the availability of large ASD cohorts, the contribution of many genes overall, and small effect sizes attributable to common gene variants. An alternative approach is to use a model organism to detect alleles that impact ASD-relevant behaviors and ask whether homologous human genes infer ASD risk. Here we utilized the Drosophila genetic reference panel (DGRP) as a tool to probe for perturbation in naturally occurring behaviors in that are analogous to three behavior domains: impaired social communication, social reciprocity and repetitive behaviors or restricted interests.
View Article and Find Full Text PDFThe alternative oxidase (AOX) is a non-protonmotive ubiquinol oxidase that is found in mitochondria of all higher plants studied to date. Structural and functional characterisation of this important but enigmatic plant diiron protein has been hampered by an inability to obtain sufficient native protein from plant sources. In the present study recombinant SgAOX (rSgAOX), overexpressed in a ΔhemA-deficient Escherichia coli strain (FN102), was solubilized from E.
View Article and Find Full Text PDFPurpose: To retrospectively evaluate the efficacy and complications of endobronchial stent placement for the management of airway complications following lung transplant.
Materials And Methods: From 1992 to 2003, tracheobronchial stenting was performed on 25 lung transplant recipients (16 male and 9 female; mean age 51.6 years; range 21-65 years).