On the go with Toe & Flow: Private Clinic Design and Flow.

Lower extremity amputation secondary to diabetes and/or peripheral artery disease is a significant health issue globally. Many amputation prevention programs exist in academic settings; however, given the increasing administrative burdens associated with large institutions, it can be challenging to develop and maintain such programs in the modern era. Private amputation prevention clinics may be a viable alternative, allowing for greater control over services provided and better ability to meet patient needs.

Mechanism of arsenic regulation of mitochondrial damage and autophagy induced synaptic damage through SIRT1 and protective effect of melatonin.

Arsenic (As), a widespread environmental pollutant, can induce severe neurological damage worldwide; however, the underlying mechanisms remain unclear. Sirtuin 1 (SIRT1) has been reported to exert neuroprotective effects against various neurological diseases by resisting mitochondrial damage and autophagy through deacetylation. In this study, we established a model of HT22 cells exposed to NaAsO and examined the levels of mitochondrial, autophagy, and synaptic damage in HT22 cells and HT22 cells with high expression of SIRT1 (pre-treated with the agonist SRT1720) 24 h after exposure.

A mobile health application that supports a patient centered approach to cardiovascular risk management.

Digital health tools have the potential to support patients in managing their chronic diseases. Recently, Ullrich and colleagues (2025) introduced , a mobile health application that provides patients with up-to-date ultrasound images of their carotid plaques and tracks their lifestyle habits. Through a randomized controlled trial, the authors provide evidence of PreventiPlaque’s efficacy in improving patients’ cardiovascular risk profiles.

Using Machine Learning to Predict Outcomes Following Thoracic and Complex Endovascular Aortic Aneurysm Repair.

Background: Thoracic endovascular aortic repair (TEVAR) and complex endovascular aneurysm repair (EVAR) are complex procedures that carry a significant risk of complications. While risk prediction tools can aid in clinical decision making, they remain limited. We developed machine learning algorithms to predict outcomes following TEVAR and complex EVAR.

A new metric to understand the association between heart rate variability and menstrual regularity.

Cardiovascular disease is underdiagnosed and undertreated in women compared to men. Wearable technologies (wearables) help shed light on women’s cardiovascular by collecting continuous cardiovascular data and correlating it with hormonal fluctuations across the menstrual cycle. In this context, Jasinski et al.

Using machine learning to predict outcomes following transcarotid artery revascularization.

Transcarotid artery revascularization (TCAR) is a relatively new and technically challenging procedure that carries a non-negligible risk of complications. Risk prediction tools may help guide clinical decision-making but remain limited. We developed machine learning (ML) algorithms that predict 1-year outcomes following TCAR.

Telemedicine expands cardiovascular care in China - lessons for health equity in the United States.

Liu et al.’s recent study reveals that telemedicine expanded access to cardiovascular care in China, enabling patients in poorer areas of the country to access care in cities with more resources. While these findings may support the global expansion of telemedicine, implementation often proves challenging.

High-Performance Bi-Based Catalysts for CO₂ Reduction: In Situ Formation of Bi/Bi₂O₂CO₃ and Enhanced Formate Production.

The unavoidable self-reduction of Bismuth (Bi)-based catalysts to zero-valence Bi often results in detrimental adsorption of OCHO, leading to unsatisfactory selectivity of HCOOH in the electroreduction of carbon dioxide (CO). A novel Bi-tannin (Bi-TA) complex is developed, which undergoes in situ reconstruction into a Bi/Bi₂O₂CO₃ phase during CO reduction. This reconstructed catalyst exhibits high activity and selectivity, achieving a Faradaic Efficiency (FE) for formate production exceeding 90%, peaking at 96%.

Synthesis, Preclinical Evaluation, and First-in-Human Assessment of ICG-PSMA-D5: A PSMA-Targeted Probe for Fluorescence-Guided Surgery of Prostate Cancer.

Precise surgical resection of prostate cancer (PCa) is a significant clinical challenge due to the impact of positive surgical margins on postoperative outcomes. Fluorescence-guided surgery (FGS) enables real-time tumor visualization using fluorescent probes. In this study, we synthesized and evaluated an indocyanine green (ICG)-based PSMA-targeted near-infrared probe, , for intraoperative imaging of PCa lesions.

Reconstruction of local three-dimensional temperature field of tumor cells with low-toxic nanoscale quantum-dot thermometer and cepstrum spatial localization algorithm.

The optimal method for three-dimensional thermal imaging within cells involves collecting intracellular temperature responses while simultaneously obtaining corresponding 3D positional information. Current temperature measurement techniques based on the photothermal properties of quantum dots face several limitations, including high cytotoxicity and low fluorescence quantum yields. These issues affect the normal metabolic processes of tumor cells.

Review of Short-Wavelength Infrared Flip-Chip Bump Bonding Process Technology.

Short-wave infrared (SWIR) imaging has a wide range of applications in civil and military fields. Over the past two decades, significant efforts have been devoted to developing high-resolution, high-sensitivity, and cost-effective SWIR sensors covering the spectral range from 0.9 μm to 3 μm.

Nomogram for pre-procedural prediction of lymph node metastasis in patients with submucosal early gastric cancer.

Background: The treatment of early gastric cancer (EGC) is contingent upon the status of lymph node metastasis (LNM). Accurate preoperative prediction of LNM is critical for reducing unnecessary surgeries. This study seeks to evaluate the risk factors for LNM in submucosal EGC and develop a predictive model to optimize therapeutic decision-making.

Prediction of Major Adverse Cardiovascular Events in Patients with Peripheral Artery Disease Using Circulating Immunomodulatory Proteins.

The leading cause of death for people with peripheral artery disease (PAD) is major adverse cardiovascular events (MACE), including heart attacks and strokes. However, research into biomarkers that could help predict MACE in patients with PAD has been limited. Immunomodulatory proteins are known to significantly influence systemic atherosclerosis, suggesting they could be useful prognostic indicators for MACE in patients with PAD.

Characterization of the Mitochondrial Genome of (Astacidea: Cambaridae) and Its Phylogenetic Implications.

Background: is an endangered freshwater crayfish in China, belonging to the genus Cambaroides, that can act as a complementary host for paragonimus. The objective of this study was to examine the complete mitochondrial genome characteristics and their evolutionary relationships within the Astacidea.

Methods: The analysis of gene rearrangements and evolutionary relationships was conducted through the sequencing of the mitochondrial genome of .

Predicting lack of clinical improvement following varicose vein ablation using machine learning.

Objective: Varicose vein ablation is generally indicated in patients with active/healed venous ulcers. However, patient selection for intervention in individuals without venous ulcers is less clear. Tools that predict lack of clinical improvement (LCI) after vein ablation may help guide clinical decision-making but remain limited.

Identification and Evaluation of Angiogenesis-Related Proteins That Predict Major Adverse Cardiovascular Events in Patients with Peripheral Artery Disease.

Background: The most common cause of death in patients with peripheral artery disease (PAD) are major adverse cardiovascular events (MACEs), including myocardial infarction (MI) and stroke. However, data on biomarkers that could be used to help predict MACEs in patients with PAD to guide clinical decision making is limited. Angiogenesis-related proteins have been demonstrated to play an important role in systemic atherosclerosis and may act as prognostic biomarkers for MACEs in patients with PAD.

Study on the use of intravascular ultrasound-guided coronary intravascular lithotripsy compared with rotational atherectomy: a single-center, retrospective study.

Objective: This study aimed to compare the efficacy and safety of intravascular ultrasound (IVUS)-guided coronary intravascular lithotripsy and rotational atherectomy in treating severe coronary artery calcification.

Methods: A retrospective analysis of 60 patients who underwent percutaneous coronary intervention at the General Hospital of Ningxia Medical University from October 2022 to August 2023 was conducted. The patients were divided into two groups: 30 received IVUS-guided coronary intravascular lithotripsy and 30 underwent IVUS-guided rotational atherectomy.

Investigation of the Potential Material Basis and Mechanism of Astragali Radix Against Adriamycin-Induced Nephropathy Model Rat by H NMR and MS-Based Untargeted Metabolomics Analysis.

Astragali Radix (AR) is one of the monarch drugs of Fangji Huangqi decoction and has the effects of inducing diuresis to alleviate edema, tonifying and strengthening the body. However, there is a paucity of research regarding the effective fraction and the underlying metabolic mechanism of AR on nephrotic syndrome (NS). This work aims to elucidate the potential mechanisms of AR treating NS, as well as to identify effective part and components.

Prioritizing landscapes for mitigating the impacts of onshore wind farms on multidimensional waterbird diversity in the Yellow Sea.

Ongoing wind energy developments play a key role in mitigating the global effects of climate change and the energy crisis; however, they have complex ecological consequences for many flying animals. The Yellow Sea coast is considered as an ecological bottleneck for migratory waterbirds along the East Asian-Australasian flyway (EAAF), and is also an important wind farm base in China. However, the effects of large-scale onshore wind farms along the EAAF on multidimensional waterbird diversity, and how to mitigate these effects, remain unclear.

The Impact of Telehealth Implementation and Visit Modality on No-Show Rate in a High-Risk Obstetrics Clinic in a Safety Net Healthcare System.

Few studies have explored patient choice of visit modality between in-person, video, and telephone for prenatal care where exams are viewed as core to care and how this choice impacts no-show rate. This study evaluated the association between choice of visit modality and prenatal care visit attendance. In this observational (July 2020-June 2022) mixed methods study of an urban safety-net obstetrics clinic, we collected sociodemographic traits, telemedicine eligibility (as determined by a clinician), choice of visit modality (in-person, telephone, and video), and visit completion status.

Prediction of Major Adverse Limb Events in Females with Peripheral Artery Disease using Blood-Based Biomarkers and Clinical Features.

The objective of this study was to identify a female-specific prognostic biomarker for peripheral artery disease (PAD) and develop a prediction model for 2-year major adverse limb events (MALE). Patients with/without PAD were recruited (n=461). Plasma concentrations of 68 circulating proteins were measured and patients were followed for 2 years.