Publications by authors named "Ben J Gross"
Article Synopsis
- Scientists are studying how certain areas in the body called signalling centres help organs grow during the early stages of development.
- They found that in rodent teeth, a key signalling centre called the enamel knot is formed because of pressure created by cells multiplying.
- By changing cell growth or applying pressure, they learned that this mechanical stress is important for the formation of the enamel knot, which helps dictate how teeth develop.
Microscopy imaging of mouse growth plates is extensively used in biology to understand the effect of specific molecules on various stages of normal bone development and on bone disease. Until now, such image analysis has been conducted by manual detection. In fact, when existing automated detection techniques were applied, morphological variations across the growth plate and heterogeneity of image background color, including the faint presence of cells (chondrocytes) located deeper in tissue away from the image's plane of focus, and lack of cell-specific features, interfered with identification of cell.
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