Enantioselective Synthesis of β-Aminoboronic Acids via Borylalkylation of Enamides.

Aminoboronic acids represent a class of significant compounds that have attracted significant attention in the fields of drug discovery and organic synthesis. Despite notable progress in their synthesis, the efficient construction of chiral β-aminoboronic acids with alkyl side chains remains a challenging endeavor. Here, we introduce an unprecedented nickel-catalyzed asymmetric borylalkylation of enamides, employing a simple chiral diamine ligand, readily available Bpin, and alkyl halides as coupling partners.

Experimental and simulation investigation of stereo-DIC via a deep learning algorithm based on initial speckle positioning technology.

For the deep-learning-based stereo-digital image correlation technique, the initial speckle position is crucial as it influences the accuracy of the generated dataset and deformation fields. To ensure measurement accuracy, an optimized extrinsic parameter estimation algorithm is proposed in this study to determine the rotation and translation matrix of the plane in which the speckle is located between the world coordinate system and the left camera coordinate system. First, the accuracy of different extrinsic parameter estimation algorithms was studied by simulations.

Enantioselective C-H Arylation for Axially Chiral Heterobiaryls.

An enantioselective palladium-catalyzed C-H arylation of functionalized pyrazoles/triazoles/imidazoles is developed, affording a variety of axially chiral -nitro/formyl-substituted heterobiaryls with excellent enantioselectivities and good yields. The method features a deuterated P-chiral phosphorus ligand CD-AntPhos, a broad substrate scope of functionalized heterobiaryls, mild reaction conditions, and low palladium loadings.

Model for Predicting Central Nervous System Relapse in Diffuse Large B-Cell Lymphoma and Discussion of Prophylaxis Measures.

Objective: Relapse of the central nervous system (CNS) is a rare but fatal complication in diffuse large B-cell lymphoma (DLBCL). The purpose of this study is to learn how to identify high-risk patients and take effective preventive measures.

Methods: We retrospectively analyzed 1,290 adult patients with DLBCL at Peking University Cancer Hospital and Shanxi Bethune Hospital between 2010 and 2020.

Value of the controlling nutritional status score and psoas muscle thickness per height in predicting prognosis in liver transplantation.

Background: Patients with end-stage liver disease usually have varying degrees of malnutrition, and severe malnutrition may affect the prognosis of patients after liver transplantation (LT). However, there is no recommended standard for the nutrition assessment of patients waiting for LT, and it is unknown whether malnutrition has an impact on the occurrence of postoperative complications.

Aim: The study aim was to investigate the value of the controlling nutritional status (CONUT) score and psoas muscle thickness per height (PMTH) in predicting prognosis in LT.

Waterlogging and salinity effects on two Suaeda salsa populations.

Adaptations to combined salinity and waterlogging stress were evaluated in two Suaeda salsa populations from different saline environments. Seedlings were exposed to 1, 200 and 600 mM NaCl in drained or waterlogged sand for 22 days in a glasshouse. Waterlogging did not significantly affect the K(+) /Na(+) ratio or Cl(-) concentration in leaves of either population.

Detection of unsaturated disaccharides, pyridinoline, and hydroxyproline in urine of patients with Kashin-Beck disease: comparison with controls in an endemic area.

Objective: To investigate the pathologic status of adult patients with Kashin-Beck disease (KBD) in an endemic area of China through detection of 5 biochemical markers in their urine, and to study the correlations between these markers and KBD.

Methods: A total of 55 patients with KBD over age 40 years were recruited and divided into groups, Grade 1 and Grade 2, according to clinical diagnosis criteria for KBD and our inclusion criteria; 25 healthy persons were enrolled into a control group. The first-time urine of the 80 participants was collected in the morning.