Publications by authors named "Ben D-M Chen"
Cleavage of Bcl-2 Protein by Activated Caspase-3 Is Associated with Inactivation of Lyn(p53/56) Kinase Activity in Human M-07e Leukemic Cells during Apoptosis.
Zhongguo Shi Yan Xue Ye Xue Za Zhi
September 2000
Article Synopsis
- The growth of M-07e human megakaryocytic leukemia cells relies heavily on GM-CSF, which activates the GM-CSF receptor composed of two subunits affecting cell survival.
- Removal of GM-CSF leads to decreased lyn kinase activity, resulting in growth inhibition and apoptosis characterized by the cleavage of Bcl-2 and Bax proteins.
- TGF-beta 1 also promotes apoptosis in these cells by inactivating lyn kinase and inducing a similar pattern of protein cleavage without affecting the receptor's subunit levels or interactions.