Publications by authors named "Ben Colton"
Article Synopsis
- Autoimmune polyendocrine syndrome type 1 (APS-1) is a severe genetic disorder resulting from AIRE deficiency, leading to self-reactive T cells causing autoimmune damage in various organs.
- The study investigated the role of interferon-γ in APS-1 by analyzing patient samples and conducting experiments with mice, finding that high levels of interferon-γ correlate with disease activity.
- Treatment with the JAK inhibitor ruxolitinib significantly reduced interferon-γ levels and improved symptoms in APS-1 patients, suggesting that targeting this pathway may be a viable therapeutic approach.
Article Synopsis
- An opportunistic mold can lead to lung infections in people with weakened immune systems, often treated with triazole drugs.
- Lupus nephritis, a serious kidney problem in lupus patients, requires treatments that can interact negatively with triazoles, leading to increased toxicity.
- The case study highlights a patient with both pneumonia and lupus nephritis who was effectively treated using posaconazole and echinocandin interruptions, allowing safe cyclophosphamide therapy that improved both lung and kidney health.
Integrating the revenue cycle for improved health system performance.
Healthc Financ Manage
January 2015
Three integrated revenue cycle models reflect the various levels of integration a health system'might find desirable or feasible based on its current circumstances and environment: Model A: A single health system executive provides oversight, but physician and hospital revenue cycles are managed separately. Model B: A single health system leader provides oversight, with a functional framework for management at the director level. Model C: Integration is complete for all processes.
View Article and Find Full Text PDFBackground: Tenofovir associated nephrotoxicity (TDFN) is well recognized. This study describes the trend of renal function recovery and virologic consequences after cessation of tenofovir (TDF) for suspected TDFN.
Methods: This was a retrospective chart review of 241 patients who underwent HLA-B*5701 allele testing between January 2007-December 2010.