Publications by authors named "Ben Aguilar"
Article Synopsis
- Relapsing polychondritis (RPC) is a rare autoimmune disorder that primarily affects cartilaginous tissues, especially leading to painful swelling of the ear, and often mimics recurrent external ear infections.
- A 74-year-old male with a history of vascular disease experienced repeated painful swelling of his right ear, misdiagnosed as otitis externa, and showed elevated inflammatory markers and antinuclear antibodies in lab tests.
- After inadequate results from antibiotics and anti-inflammatory treatments, he was started on prednisone and referred to rheumatology for further management of his recurrent ear issues.
Detection of host cell protein (HCP) impurities is critical to ensuring that recombinant drug products, including monoclonal antibodies (mAbs), are safe. Mechanistic characterization as to how HCPs persist in drug products is important to refining downstream processing. It has been hypothesized that weak lipase-mAb interactions enable HCP lipases to evade drug purification processes.
View Article and Find Full Text PDF