Urban delineation through a prism of intraday commute patterns.

Introduction: Urban mobility patterns are crucial for effective urban and transportation planning. This study investigates the dynamics of urban mobility in Brno, Czech Republic, utilizing the rich dataset provided by passive mobile phone data. Understanding these patterns is essential for optimizing infrastructure and planning strategies.

Unraveling the Central Role of Sulfur-Oxidizing LMS in Industrial Bioprocessing of Gold-Bearing Sulfide Concentrates.

LMS is an acidophile isolated from industrial bioreactors during the processing of the gold-bearing pyrite-arsenopyrite concentrate at 38-42 °C. Most strains of this species are obligate organoheterotrophs that do not use ferrous iron or reduced sulfur compounds as energy sources. However, the LMS strain was identified as one of the predominant sulfur oxidizers in acidophilic microbial consortia.

The Resistance of to Oxidative, Genotoxic, Proteotoxic, Osmotic Stress, Infection, and Starvation Depends on Age According to the Stress Factor.

We studied how aging affects the ability of to tolerate various types of stress factors. Data were obtained on the resistance of to oxidative and genotoxic (separately paraquat, Fe, Cu, and Zn ions), proteotoxic (hyperthermia, Cd ions), and osmotic (NaCl) stresses, starvation, and infection with the pathological fungus at different ages. In all cases, we observed a strong negative correlation between age and stress tolerance.

The Influence of Chromosomal Environment on X-Linked Gene Expression in Drosophila melanogaster.

Sex chromosomes often differ from autosomes with respect to their gene expression and regulation. In Drosophila melanogaster, X-linked genes are dosage compensated by having their expression upregulated in the male soma, a process mediated by the X-chromosome-specific binding of the dosage compensation complex (DCC). Previous studies of X-linked gene expression found a negative correlation between a gene's male-to-female expression ratio and its distance to the nearest DCC binding site in somatic tissues, including head and brain, which suggests that dosage compensation influences sex-biased gene expression.

Quantifying segregation in an integrated urban physical-social space.

Our knowledge of how cities bring together different social classes is still limited. Much effort has been devoted to investigating residential segregation, mostly over well-defined social groups (e.g.

Transcriptome analysis reveals mechanisms of geroprotective effects of fucoxanthin in Drosophila.

Background: We have previously showed that the carotenoid fucoxanthin can increase the lifespan in Drosophila melanogaster and Caenorhabditis elegans. However, the molecular mechanisms of the geroprotective effect of fucoxanthin have not been studied so far.

Results: Here, we studied the effects of fucoxanthin on the Drosophila aging process at the molecular and the whole organism levels.

Global multi-layer network of human mobility.

Recent availability of geo-localized data capturing individual human activity together with the statistical data on international migration opened up unprecedented opportunities for a study on global mobility. In this paper, we consider it from the perspective of a multi-layer complex network, built using a combination of three datasets: Twitter, Flickr and official migration data. Those datasets provide different, but equally important insights on the global mobility - while the first two highlight short-term visits of people from one country to another, the last one - migration - shows the long-term mobility perspective, when people relocate for good.

The influence of pro-longevity gene Gclc overexpression on the age-dependent changes in Drosophila transcriptome and biological functions.

Background: Transcriptional changes that contribute to the organism's longevity and prevent the age-dependent decline of biological functions are not well understood. Here, we overexpressed pro-longevity gene encoding glutamate-cysteine ligase catalytic subunit (Gclc) and analyzed age-dependent changes in transcriptome that associated with the longevity, stress resistance, locomotor activity, circadian rhythmicity, and fertility.

Results: Here we reproduced the life extension effect of neuronal overexpression of the Gclc gene and investigated its influence on the age-depended dynamics of transcriptome and biological functions such as fecundity, spontaneous locomotor activity and circadian rhythmicity, as well as on the resistance to oxidative, proteotoxic and osmotic stresses.

[ROLE OF NEUTRAL SPHINGOMYELINASE IN AGE-DEPENDENT MUSCLE INSULIN RESISTANCE DEVELOPMENT AND ITS IMPROVEMENT WITH N-ACETYLCYSTEINE].

In the present study, we evaluated the role of ceramide in age-dependent and etoposide-induced insulin resistance. A significant increase in the level of ceramide and decrease of gluthatione (GSH) content and tissue sensitivity to insulin has been observed in 24-month-old rats as compared with 3-month-old animals. Etoposide imitates ageing-like changes in muscle tissue of young rats.

[Effect of temperature on the rate of oxidation of pyrrhotite-rich sulfide ore flotation concentrate and the structure of the acidophilic chemolithoautotrophic microbial community].

Oxidation of flotation concentrate of a pyrrhotite-rich sulfide ore by acidophilic chemolithoautotrophic microbial communities at 35, 40, and 45 degrees C was investigated. According to the physicochemical parameters of the liquid phase of the pulp, as well as the results of analysis of the solid residue after biooxidation and cyanidation, the community developed at 40 degrees C exhibited the highest rate of oxidation. The degree of gold recovery at 35, 40, and 45 degrees C was 89.

General optimization technique for high-quality community detection in complex networks.

Recent years have witnessed the development of a large body of algorithms for community detection in complex networks. Most of them are based upon the optimization of objective functions, among which modularity is the most common, though a number of alternatives have been suggested in the scientific literature. We present here an effective general search strategy for the optimization of various objective functions for community detection purposes.

[Selection of a community of acidochemolithotrophic microorganisms with a high oxidation rate of pyrrhotite- containing sulphide ore flotatation concentrate].

A community of acidochemolithotrophic microorganisms with a high oxidation rate of pyrrhotite-containing sulphide ore flotation concentrate was selected. The Acidithiobacillus caldus OP-1 and Ferroplasma acidiphilum OP-2 cultures were identified to be dominating members. The presence of the Acidithio- bacillusferrooxidans OP-3, Leptospirillumferriphilum OP-4, and Sulfobacillus thermosulfidooxidans OP-5 cultures in the community's composition was also mentioned.

[Oxidation of sulfur-containing substrates by aboriginal and experimentally designed microbial communities].

Aboriginal and experimental (constructed of pure microbial cultures) communities of acidophilic chemolithotrophs have been studied. The oxidation of elemental sulfur, sodium thiosulfate, and potassium tetrathionate as sole sources of energy has been monitored. The oxidation rate of the experimental community is higher as compared to the aboriginal community isolated from a flotation concentrate of pyrrhotine-containing pyrite-arsenopyrite gold-arsenic sulfide ore.

[Bacterial leaching of manganese ores].

Leaching of various types of ores, containing 12-30% manganese, by the thiobacterium Acidithiobacillus ferrooxidans was studied. Leaching of reduced ores (manganocalcite and manganiferous limestone) was mediated mainly by degradation of manganiferous minerals (by sulfuric acid produced in the course of bacterial oxidation of pyrite or sulfur). Bacterial treatment of the ores for 144 and 192 h allowed solubilization of 96-98% of manganese.

[Metabolic acidosis under an acid load and the role of the respiratory system in its compensation in middle-aged and elderly persons].

30 healthy 60- to 89-year-old subjects and 20 young ones (20 to 31 years) were given orally ammonium chloride 125 mg/kg. The signs of subsequent metabolic acidosis were more obvious in older subjects and they lasted longer. In young subjects, the intake of ammonium chloride induced a considerable hyperventilation.

[Age-related characteristics of the pharmacokinetics of acetylsalicylic acid].

Acetylsalicylic acid pharmacokinetics was studied in young, elderly and old patients after a single oral administration in a dose of 14 mg/kg. The pharmacokinetics data may be formalized by means of the one-compartment model with absorption. Constants of absorption and elimination, total clearance value are decreased with age.

[Age-related characteristics of the functional state of kidneys (radiorenography data)].

Renal function of 91 healthy subjects aged 18-91 has been evaluated at radionuclide renography with the use of 131I-Hippuran. Renal excretory function, effective renal plasma and blood flows were found to decrease annually by 0.09 ml/kg in ageing men and by 0.