[Quantitative susceptibility mapping in assessment of inflammation and neurodegeneration in multiple sclerosis].

Quantitative susceptibility mapping (QSM) is a relatively new MRI technique that may potentially help estimate iron concentrations in the brain. It plays a big role in diagnosis of many pathological processes, including multiple sclerosis (MS). Iron metabolism in the brain is a complex and not fully understood process.

The randomized clinical trial results of the anxiety treatment in patients with somatoform dysfunction and neurotic disorders.

The existing treatments for somatoform dysfunction (SfD), reaction to severe stress (RSS), and adjustment disorders (AjD) are insufficiently effective and safe. Anxiolytic drug Tenoten proved effective in clinical trials (CT). The aim of this multicenter double-blind placebo-controlled randomized CT was to investigate the safety and efficacy of Tenoten in the treatment of anxiety in adults with SfD, RSS, AjD and other neurotic disorders (oNDs).

[Modern neuroprotection in the treatment of patients with cerebrovascular diseases].

Currently, both in Russia and in the world as a whole, the problem of acute and chronic cerebrovascular pathology does not lose its relevance, despite the organizational measures taken to prevent and treat this pathology. The search for highly effective methods of treating stroke patients continues, while preference is given to drugs with polymodal neuroprotective, neuroreparative effects. In this regard, the promising Russian drug cellex, obtained from the embryonic brain tissue of pigs, is of interest.

[Acupuncture in the prevention and treatment of stroke: a review of foreign studies].

Acupuncture has been recommended by the World Health Organization (WHO) as an alternative and complementary method for treating stroke and a way to increase the effectiveness of rehabilitation. The data available in the literature suggest that acupuncture has a beneficial effect on the status of patients with stroke. The mechanism of action of acupuncture for stroke includes the following components: 1) stimulation of neurogenesis and cell proliferation in the CNS; 2) regulation of cerebral blood flow; 3) antiapoptosis; 4) regulation of neurotransmitters; 5) improvement of the neuronal synaptic function, stimulation of long-term potentiation; 6) stimulation of neuroplasticity; and 7) decrease in blood-brain barrier permeability.

[Dose-dependent effects of cortexin in chronic cerebral ischemia (results of a multicenter randomized controlled study)].

Aim: To study an effect of cortexin on neurological symptoms and oxidative stress as part of the ischemic cascade in chronic cerebral ischemia (CCI), I-II stages.

Material And Methods: The multicenter randomized controlled study included 189 patients with CCI, 42 (22.2%) men and 147 (77.

[Primary-progressive multiple sclerosis in Russia: a medical-sociological study involving patients and neurologists].

The main results of a medical-sociological study aimed at the evaluation of the level of satisfaction with treatment in patients with primary progressive multiple sclerosis (PPMS) are presented. The survey was conducted in 19 regions of the Russian Federation and involved 437 patients with confirmed diagnosis of PPMS and 80 neurologists specialized in multiple sclerosis. The research was carried out by the All-Russian Public Organization of Disabled People with Multiple Sclerosis with the participation of the Russian Committee for Treatment and Research in Multiple Sclerosis.

[Primary progressive multiple sclerosis: current issues of timely diagnosis].

This article presents a review of international data on primary progressive multiple sclerosis (PPMS) and an analysis of factors influencing timely diagnosis of PPMS in a number of regions of the Russian Federation.

[Cognitive disorders in stroke patients: the possibilities of pharmacological correction].

Objective: To determine the efficacy and safety of cellex in treatment of cognitive disorders in acute ischemic stroke (IS).

Material And Methods: The study involved 246 patients with acute IS. Patients were randomly divided into two groups depending on the use of cellex or placebo along with basic treatment during 10 days.

[Possibilities of the treatment of speech impairment in the acute stage of ischemic stroke using neuroprotective therapy].

Aim: To estimate an effect of cellex on the dynamics and time of speech functions recovery in the acute stage of ischemic stroke.

Material And Methods: A multicenter, randomized, double-blind, placebo controlled clinical study included 8 Russian clinical sites. Four hundred eighty patients were involved.

[An analysis of treatment of the Russian group of patients in the international observational study «Factors influencing response to botulinum toxin type A in patients with idiopathic cervical dystonia»].

Aim: The analysis of the results of treatment of the Russian patient population in the frame of international, multicenter, non-interventional study of CD, the primary purpose of which was to determine the response rate to therapy with BTA at the peak of the effect: after one course of injections in settings of routine practice, as well as the results of application of modern definition for "response" to treatment with BTA.

Material And Methods: In Russia 60 patients with idiopathic CD were included. Patients were classified as «responders» according to the following 4 criteria: effect size (improvement by ≥ 25% assessed by TWSTRS); effect duration: ≥ 12 weeks interval between the BTA injection and the day when the patient reported a decrease of clinical effect, indicating the need for repeated treatment; good tolerability of treatment (no treatment-related serious adverse events (AEs) during the study period); patient-reported Clinical Global Improvement (CGI) score is +2 («significant improvement») or +3 («very significant improvement») at the visits 2 or 3.

[New possibilities of pharmacological treatment of adult epilepsy].

Objective: To study an effect of cortexin on epilepsy course and electroencephalographic pattern in stopping the symptoms concomitant to epilepsy.

Material And Methods: A study included 64 patients with epilepsy (22 men and 42 women, aged from 20 to 85 years). Along with standard treatment, the patients received cortexin (three 10-day courses during 12 months intramuscular in dose 10 mg daily).

[Efficacy of the combination drug vasobral in chronic vascular encephalopathy].

Objective: Despite the high prevalence of chronic vascular encephalopathy, its diagnosis and treatment remain understudied. This observational multicenter trial assessed the efficacy and safety of vasobral in patients with cerebral ischemia.

Material And Methods: The open observational study was carried out in 37 centers in 11 Russian cities and included 300 patients with confirmed diagnosis of chronic vascular encephalopathy, stages 1 and 2, without dementia.

Experience in the use of Actovegin in the treatment of patients with cognitive disorders in the acute period of stroke.

Forty-three patients with mild-moderate ischemic stroke were studied in the acute period and were divided into two groups. The experimental group consisted of 32 patients who were given Actovegin; the reference group consisted of 11 patients who were given piracetam. Patients were investigated before treatment and at 10 and 30 days; investigations included examination, points assessments of neurological disorders using the original Gusev-Skvortsova scale, neuropsychological tests using the MMSE scale, rheoencephalography, and electroencephalography.