[Analysis of the spectrum of bacterial pathogens isolated from patients with complicated skin and soft tissue infections presumably due to grampositive or mixed flora in the countries of the Central and East Europe].

The data on the microbiological investigation of clinical materials from patients with complicated skin and soft tissue infections in 6 European countries were analysed. The analysis of the bacterial pathogens spectrum provided the microbial view and efficient use of novel antimicrobials in clinical trials.

[Photo-hemo-correction in the complex treatment of patients with obliterating atherosclerosis of the arteries of the lower limbs].

Based on the assessment of clinical efficiency of the intravascular and percutaneous photomodification of blood with a helium-neon laser in 170 patients the authors have shown that it is expedient to include the photohemocorrection in the medical programs for the I-III degree ischemia.

[Feasibility of correction of blood aggregation properties in the course of extracorporeal hemosorption in atherosclerosis patients].

Aggregation and rheological properties of blood were evaluated in 20 atherosclerotic patients after cryoplasmosorption. The change of the patients' plasma for extracorporeally modified autoplasma reduced coagulation potential, enhanced fibrinolysis and suppressed anticoagulation systems. Clinical efficacy manifested in decreased frequency and duration of anginal episodes, intensity of intermittent claudication.

[Activity of free radical lipid oxidation and the state of antioxidant system in patients with ischemic heart disease during myocardial revascularization].

It has been established that aortocoronary bypass surgery is characterized by imbalance in lipid peroxidation and antioxidant defense system. These changes are more pronounced in patients with the most severe forms of ischemic heart disease. During surgery the greatest intensity of lipid peroxidation is observed at the end of assisted circulation period.

[Cryohemosorption--a method of removal of lipoprotein-antibody immune complexes and other atherogenic substances in patients with atherosclerosis].

The efficacy of extracorporeal cryohemosorption was estimated in the treatment of atherosclerotic patients in terms of the autoimmune theory of the pathogenesis of this disease. There was a slight decrease in the plasma levels of total cholesterol and triglycerides, there was over 2-fold reduction in the plasma levels of fibrinogen and fibronectin. All major components of apo B-containing lipoproteins and immunoglobulin G were found as part of the cryoprecipitate.

[Effects of plasmapheresis on the activity of lipid peroxidation in peritonitis].

The destructive process in the abdominal cavity leading to peritonitis is accompanied by the activation of free-radical lipid oxidation which promotes the disturbances of cellular membrane integrity and the development of endotoxemia. Hemodilution and plasmapheresis decreased the blood level of lipid peroxidation products and activated the system of antioxidant protection.

[The storage and preparation of autologous plasma for transfusions to patients with arteriosclerosis obliterans of the vessels of the lower extremities].

An investigation of the regimen of storage and sorption of plasma in patients with obliterating atherosclerosis of lower extremity vessels has shown that the optimum regimen of storage of plasma is freezing (with addition of 1 thousand of heparin units per 100 ml of plasma) at t = -20 degrees C followed by thawing at t = +6(+/- 2) degrees C in running water before sorption. The optimal sorbent for sorption of plasma of patients with obliterating atherosclerosis of lower extremity vessels is "Actilen" charcoal. The optimal method of sorption is sorption after thawing the plasma.

[Endogenous intoxication syndrome in patients in late stages of obliterating atherosclerosis in vessels of lower extremities].

The composition of blood was evaluated (parameters of blood clinical analysis, figures of lipid peroxidation processes and system of antioxidant protection, traditional biochemical blood parameters, total proteolytic activity and peptides of blood plasma, quantity and activity of some parameters of humoral immunity) in patients with late stages of peripheral atherosclerosis. It was showed that chronic endotoxicosis appeared in these patients. The processes of chronic endotoxicosis are compensated in patients with the 3-d stage of low extremities ischemia.

[Response of the pro- and antioxidant systems to plasmapheresis in patients with advanced atherosclerosis obliterans of the legs].

The effects of fractional apparatus plasmapheresis in a volume of 25% of circulating blood plasma on the processes of lipid peroxidation and on the antioxidant defence system parameters were studied in 31 patients with ischemia of the lower limbs, stage III-IV. It has been shown that plasmapheresis induces elevation of ceruloplasmin activity and superoxide dismutase activity of blood plasma, lowers the ratio of lipid oxidation to lipid peroxidation products simultaneously with intensification of lipid peroxidation that leads to regeneration of biological membranes of the body.

[The effect of hemosorption on the activity of free radical oxidation in destructive diseases of the abdominal cavity organs].

Depletion of antioxidant system which accompanies excessive formation of oxygen radicals and increased activity of lipid peroxidation in destructive diseases of the abdominal organs leads to the generalization of the pathological process and severe endogenous intoxication. Hemosorption as part of intensive therapy in patients with peritonitis ensures a decrease in endotoxemia degree due to elimination of toxic LPO metabolites from the blood flow and stabilizes in the post-hemosorption period the activity of free radical reactions due to an increase in antioxidant activity.

[The role of lipid peroxidation processes in the development of complications following reconstructive surgery on the vessels of the lower extremities].

Reconstructive surgery on the vessels of the lower extremities accompanied by ischemia and the following tissue oxygenation leads to the activation of lipid peroxidation causing the destruction of cellular membranes and formation of toxic products, namely medium mass oligopeptides. The accumulation of lipid peroxidation metabolites in the blood correlates with the onset of renal-hepatic failure complicating the postoperative period.

[The role of the activation of lipid peroxidation in the pathogenesis of experimental peritonitis].

Investigation was carried out for studying the role of lipid peroxidation (LP) in the genesis of destructive process in the abdominal cavity. The model of experimental peritonitis was made on the dogs. According to the concentration of fat acids conjugates with double couplings (diene conjugates--DC), malondialdehyde (MDA) the LP activity was discovered.

[Increase in the effectiveness of microbial absorption on activated charcoal upon sorbent polarization].

The effect of Staphylococcus albus and the contact time on hydrolytic adsorption of ions on activated charcoal SKN-2K in the physiological solution (0.9% NaCl) was investigated. Experiments were performed without polarization or with cathodic and anodic polarization of the adsorbent.