[The development of management of medical organizations providing specialized primary medical sanitary care to mental patients].

Actually, in Russian health care, the organization of community-based medical care of patients with mental disorders is considered as one of requested problems to be resolved. The in-patient substituting forms of specialized primary medical and social care for mental patients create optimal conditions for treatment and rehabilitation of this group of patients without separation from familiar social environment, that in many ways reduces "personality stigmatization" and promotes returning of individual to full-fledged social life, decreasing the load on the most expensive hospital care. One of such organizational forms implemented in Moscow under the new model of provision of mental care is out-patient mental module that provides specialized primary medical and social care and is tested in conditions of basic medical organization.

[The organization of home-nursing medical care of patients with limited mobility].

The article analyzes topical issues of organization of patronage medical care of patients with restricted mobility in Moscow, considering ongoing organizational measures at various stages of implementation of new organizational form of medical sanitary care of patients of different age groups. The results of analysis of effectiveness of its functioning are presented.

[The Analysis of Actual Approaches in Evaluating Efficiency of Medical Care of Female Patients with Habitual Miscarriage].

The prevalence of habitual miscarriage varies depending on territories of the Russian Federation and other countries. The rate of premature delivery in the Moscow Zelenograd administrative okrug in 2013-2015 in average made up to 4.5%-4.

[The Development of General Practitioner Practice in the Russian Federation].

The purpose of study. To analyze problems and perspectives of development of primary medical sanitary care according the principle of general practitioner practices in the Russian Federation. The article presents historical aspects of main stages of development of service of general practices in our country.

Pharmacovigilance in Russia: current state of affairs, challenges, and prospects.

This review outlines current issues of the pharmacovigilance (PV) system in the Russian Federation, namely the present state of regulatory aspects, regulatory requirements in both Russia and the Eurasian Economic Union, and review of causes of under-reporting of adverse drug reactions. Specific attention will be focused on how the system is designed to monitor drug safety functions, reporting and accountability of pharmaceutical products, their manufacturers and medical staff, the role played by regional centers for drug-safety monitoring, and insufficient understanding of the part taken by patients in the system of PV. The prospects of the Russian PV system and its harmonization with global practice will also be discussed.

[The multicenter non-interventional, prospective observational program on the study of practical use of teraligen in patients diagnosed with autonomic disorder (START2): a local Russian experience with the use of the Russian version of The Four-Dimensional Symptom Questionnaire (4DSQ). An intermediate analysis].

Aim: To develop a new instrument able to identify pathological states and assess their changes during medication treatment. We aimed to study the typical practice of using alimemazine (teraligen) in patients with the diagnosis of autonomic nervous system disorder and to test the Russian version of @The Four-Dimensional Symptom Questionnaire@ (4DSQ) for measuring distress, depression, anxiety and somatization.

Material And Methods: We examined 3053 patients (mean age 42.

A deeper look into transcription regulatory code by preferred pair distance templates for transcription factor binding sites.

Motivation: Modern experimental methods provide substantial information on protein-DNA recognition. Studying arrangements of transcription factor binding sites (TFBSs) of interacting transcription factors (TFs) advances understanding of the transcription regulatory code.

Results: We constructed binding motifs for TFs forming a complex with HIF-1α at the erythropoietin 3(')-enhancer.

Nonlinear phase change in type II second-harmonic generation under exact phase-matched conditions.

The process of type II second-harmonic generation has been investigated theoretically. It is found that, unlike in the process of type I second-harmonic generation, phase matching is not necessary for a significant shift of the pump wave phase to be produced. The simple inequality of the intensities of interacting waves suffices for this effect to occur.