An approach to growth of Fe-Si multilayers with controlled composition profile-a way to exchange coupled thin films.

The growth, composition and structure of sandwich structures (Fe-rich layer/Si-rich layer/Fe-rich silicide layer) grown on a Si(111) surface were studied by a few complementary microscopic and spectroscopic techniques with high spatial resolution. Intermixing at the Fe/Si and Si/Fe interfaces is demonstrated. Fe-rich layers grown directly on the Si(111) surface are crystalline and have abrupt but rough interfaces at both sides.

[Cytokines and antiviral immuniy].

In the review of modern literature and results of own research about role of immunoregulation cytokines imbalance system in pathogen of deep-rooted virus infections are analyzed. The question on molecular mechanisms of cytokine chain deregulation at persistent virus infections is discussed.

[Immunoregulatory cytokines and chronization of type C hepatitis: matching of clinical and immunological manifestations].

The study demonstrates significant changes of cytokine-producing ability of mononuclear blood leucocytes in type 'hepatitis, correlating with the degree of hepatic lesion. The results showed that various morphologic types of chronic virus type C hepatitis were associated with disbalance in production of pro- and antiinflammatory cytokines, i.e.

Chronic tick-borne encephalitis virus antigenemia: possible pathogenesis pathways.

Study of the proliferative potential and immunophenotype of lymphocytes and cytokine-producing capacity of mononuclear cells in patients with chronic tick-borne encephalitis virus antigenemia showed changes in T cell lymphoproliferative response, relative content of T cells and T helper inductors, immunoregulatory index, and imbalance in the production of immunoregulatory Th1 and Th2 cytokines.

Molecular mechanisms of changes in TNF-alpha production by blood mononuclears in chronic viral hepatitis C.

Chronic viral hepatitis C is associated with decreased production of TNF-alpha by the peripheral blood mononuclear leukocytes irrespective of virus genotype and degree of the morphological activity of the process in the liver. This process positively correlates with the increase in the content of TNF-alpha soluble receptor (molecular weight 55 kDa), which can play a role in the mechanisms of immunopathogenesis of long persistence of hepatitis C virus in the body.

[The surface architectonics, functional characteristics, and metabolism in peripheral blood lymphocytes in acute herpes virus infection].

Twenty-five patients (males--11, females--14; aged 18 to 45) with chronic herpes virus infection relapsing at the time of clinical tests were examined, including investigations of the surface architectonics, the ability to blast-transformation and the metabolic status of peripheral-blood lymphocytes. Chronic herpes virus infection was found to be concurrent with changes of the percentage ratio of lymphocytes with the surface micro-patterns of different types, with a more intense activity of the immunity T-chain and with a changed nature of the intracellular metabolism of lymphocyte cells.

[Use of fluorescent probes for identifying certain animal viruses and antibodies to them].

Virus adsorption on cell receptors changed the state of cellular membranes, as was shown on a model of 25 viruses belonging to 13 families. This is indicated by an increase in the fluorescence of the DSM probe. Homologous antibodies block the virus adsorption on the cell membrane, this permitting identification of viruses and detection of antibodies to them.

[Radioimmunological study of the antigen and antibody dynamics of viral hepatitis A and B patients].

The combined radioimmunoassay of changes in the levels of HBsAg, HBaAb, HBcAb and HAAb in 34 patients with viral hepatitis, as well as in 8 patients with chronic hepatitis and in 40 normal persons, was carried out. Radioimmunoassay was made with the use of reagents manufactured by Abbot Laboratories (USA). This study showed that in infectious hepatitis the levels of HAAb in all patients were elevated already in the first decade of the disease and reached their maximum by the third decade.

[Epidemiology of viral hepatitis in the Estonian SSR].

The epidemiological peculiarities of viral hepatitis in the Estonial SSR as a whole, as well as in Tallinn and in the surrounding Harju region were studied. The study revealed that during the last 10 years the total decrease of morbidity in viral hepatitis was observed due to a decrease in infectious hepatitis, pronounced periodic and seasonal morbidity fluctuations being absent. A sharp decrease in infectious hepatitis morbidity had been achieved by carrying out planned gamma globulin prophylaxis among children.