Parazoanthus axinellae Extract Incorporated Hybrid Nanostructure and Its Potential Antimicrobial Activity.

This study, it was aimed to examine the change in the antimicrobial effect of sea anemone Parazoanthus axinellae extract by forming its nanoflowers. A scanning electron microscope (SEM) and energy dispersive X-ray spectroscopy (EDX) were expended to observe the morphologies of the Cu NFs that had been produced. Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) techniques were expended to analyze the managing assemblies in P.

Synthesis of Axinyssa digitata Extract Directed Hybrid Nanoflower and Investigation of Its Antimicrobial Activity.

First time in this study, the antibacterial effects of Axinyssa digitata sponge extracts and Axinyssa digitata-based cupper hybrid nanoflowers (Cu hNFs) were evaluated. Herein, hybrid nanoflowers (Cu hNFs) were produced by combining Axinyssa digitata sponge extract with Cu ions in Phosphate-buffered saline (PBS) (at pH 7.4) at room temperature for three days using green synthesis method.

Anti-Inflammatory, Antiallergic and COVID-19 Main Protease (M) Inhibitory Activities of Butenolides from a Marine-Derived Fungus .

Amid the current COVID-19 pandemic, the emergence of several variants in a relatively high mutation rate (twice per month) strengthened the importance of finding out a chemical entity that can be potential for developing an effective medicine. In this study, we explored ethyl acetate (EtOAc) extract of a marine-derived fungus afforded three butenolide derivatives, butyrolactones I, VI and V (-), two naphtho--pyrones, TMC-256 A1 () and rubrofusarin B () and methyl -hydroxyphenyl acetate (). Structure identification was unambiguously determined based on exhaustive spectral analyses including 1D/2D NMR and mass spectrometry.

Penicacids H-J, three new mycophenolic acid derivatives from the marine-derived fungus .

Chemical investigation of secondary metabolites in crude methanol extract of a solid rice medium of a marine-derived fungus, , has enriched the metabolic profile of this genus by affording three mycophenolic acid derivatives recognized as new fungal metabolites trivially named as penicacids H-J (1-3), along with two known naphtho-γ-pyrone dimers, asperpyrone A (4) and dianhydroaurasperone C (5). Structure elucidation of isolated compounds was unambiguously determined based on extensive 1D and 2D NMR spectroscopic analyses together with comparing coupling constant and optical rotation values with those reported for related congeners in literature. All isolated compounds were assessed for their antibacterial activity against four different bacterial microorganisms and they revealed moderate to weak activities with minimum inhibitory concentration (MIC) values ranging from 62.

Multiway resolution of spectrochromatographic measurements for the quantification of echinuline in marine-derived fungi Aspergillus chevalieri using parallel factor analysis.

A multiway resolution of incomplete chromatographic separation was presented for spectrochromatographic quantification of echinuline in marine-derived fungi Aspergillus chevalieri. Two-dimensional spectrochromatographic maps of calibration, validation and real samples were recorded as a function of time and wavelength using UPLC-PDA instrument under non-optimized chromatographic conditions, which gave rise to co-elution of echinuline and the constituents of sample matrix. A three-way array was obtained by concatenating the data matrices of the spectrochromatographic maps.

Anti-Inflammatory, Antiallergic, and COVID-19 Main Protease (M) Inhibitory Activities of Butenolides from a Marine-Derived Fungus .

In December 2020, the U.K. authorities reported to the World Health Organization (WHO) that a new COVID-19 variant, considered to be a variant under investigation from December 2020 (VUI-202012/01), was identified through viral genomic sequencing.

Ustusaustin A: a new neuraminidase inhibitory meroterpene from the ascidian-derived endophytic fungus TK-5.

A new austin-type meroterpene, namely, ustusaustin A (), together with seven related known analogues (-), were isolated and identified from the culture extract of TK-5, an endophytic fungus obtained from the marine ascidian . The structures of these compounds were established on the basis of detailed interpretation of their NMR and MS data, and the relative and absolute configurations of was confirmed by X-ray crystallographic analysis. Among them, ustusaustin A () represents the first example of 1'-nor-austin analogues with an unique 7-benzoylation.

Isolation and characterization of three pairs of indolediketopiperazine enantiomers containing infrequent N-methoxy substitution from the marine algal-derived endophytic fungus Acrostalagmus luteoalbus TK-43.

Three pairs of new N-methoxy-containing indolediketopiperazine enantiomers, acrozines A-C (1-3), were isolated from the culture extract of Acrostalagmus luteoalbus TK-43, an endophytic fungus obtained from the marine green alga Codium fragile. The optical resolution of compounds 1-3 by chiral HPLC successfully afforded individual enantiomers (+)-1/(-)-1, (+)-2/(-)-2, and (+)-3/(-)-3, respectively. The structures of all these compounds were established on the basis of detailed interpretation of their NMR and mass spectroscopic data.

Sorbicillinoid-Based Metabolites from a Sponge-Derived Fungus .

Antibacterial activity assessment and high performance liquid chromatography associated with nuclear magnetic resonance (HPLC/NMR) data revealed that the EtOAc extract of the fermented endophytic fungus DI-IA, obtained from the marine sponge , contained conjugated olefinic metabolites with antibacterial activity. Chemical examination of the fungal strain resulted in the isolation of eight new sorbicillinoid-based compounds, namely saturnispols A⁻H (⁻). Their structures were determined on the basis of extensive spectroscopic analysis, including the experimental and calculated electronic circular dichroism (ECD) data for the configurational assignments.

New Chromone, Isocoumarin, and Indole Alkaloid Derivatives from three Sponge-derived Fungal Strains.

Two new chromone derivatives, 2-hydroxymethyl-3-methyl-7-methoxychromone (1) and 2-hydroxymethyl-3-tert-butyl-7-methoxychromone (2), together with a related known compound, 2,3-dimethyl-7-methoxychromone (3), were isolated from Rhinocladiella sp. (102), a fungus obtained from the sponge Ircinia oros. Furthermore, a new isocoumarin derivative, 3-(3-chloro-2-hydroxypropyl)-8-hydroxy-6-methoxy-isochromen-I-one (4) and a known analogue 3-[(R)- 3,3-dichloro-2-hydroxypropyl]-8-hydroxy-6-methoxy-IH-isochromen-I -one (dichlorodiaportin, 5), were identified from sponge-derived fungal strain Clonostachys sp.

Lignans in flowering aerial parts of Linum species--chemodiversity in the light of systematics and phylogeny.

The aerial parts of 54 accessions representing 41 Linum species and four species of related genera were analysed for lignans by means of HPLC-ESI/MS-MS-UV/DAD. In total, 64 different lignans of the aryltetralin-, arylnaphthalene-, aryldihydronaphthalene-, dibenzylbutyrolactone-, and furofuran type were identified. According to their lignan profile, the Linum species can be divided in two groups accumulating as major lignan types either cyclolignans of the aryltetralin-series on one hand, or aryldihydronaphthalenes/arylnaphthalenes, on the other.

Hexa-, hepta- and nonaprenylhydroquinones isolated from marine sponges Sarcotragus muscarum and Ircinia fasciculata inhibit NF-kappaB signalling in H4IIE cells.

Objectives: Marine organisms have proven to be a rich source of potent pharmacologically active compounds. Three polyprenyl-1,4-hydroquinone derivates (hexaprenyl-1,4-hydroquinone, heptaprenyl-1,4-hydroquinone and nonaprenyl-1,4-hydroquinone) were isolated from the Zoobenthos-inhabiting sponges Sarcotragus muscarum and Ircinia fasciculata from the Eastern Mediterranean Sea (phylum: Porifera; class: Demospongiae).

Methods: Hexa-, hepta- and nonaprenylhydroquinone were identified by (1)H-NMR, H,H-COSY, heteronuclear multiple bond correlation, FAB-MS and UV spectroscopy.

Free Radical Scavenging Activity of Linum arboreum.

The methanol and water extracts of Linum arboreum.. aerial parts were screened for free radical scavenging activity.

Comparison of different extraction methods for the determination of podophyllotoxin and 6-methoxypodophyllotoxin in Linum species.

Three extraction methods for analysis of podophyllotoxin and its derivatives from Linum species were compared. No statistical difference on the percentage of recovery were found between the methods. The "glycosidase-method" showed the best result with respect to the accuracy studies; the "acetone-method" has an advantage compared to the other methods due to its capability to calculate the aglycone, lignan glycoside and total lignan.

Assessment of therapeutic effect of Inula heterolepsis Boiss in alcoholic rats.

An aqueous extract from the root of Inula heterolepsis Boiss was prepared and then tested for its ability to treat experimentally induced alcoholic hepatic injury in rats. Alcoholic rats were divided into two groups. The first group of rats were given 200 mg/kg/day plant extract.