Publications by authors named "Belle Sharon"

Soil is a source for diverse microbes that possess useful biotechnological capabilities. Here, we report the genome sequences of seven bacterial isolates from the species , , , , sp., and (two isolates) cultured from Dallas/Fort Worth metroplex soil samples.

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There is frequent evidence that colonizes female genitourinary tracts but few reports of . Their role in urinary tract infection (UTI) is unclear. We present the first complete genome of and a complete genome of isolated from postmenopausal women with varying UTI histories.

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Article Synopsis
  • * The rising issue of antimicrobial resistance emphasizes the need for new therapeutic targets, making it crucial to understand how pathogens like a specific bacterium associated with UTIs survive in the urinary tract.
  • * This study involved creating high-quality genomic data of bacteria isolated from postmenopausal women's urine to analyze genetic factors that may contribute to their survival in the urinary tract.
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is an understudied member of its genus possessing a characteristic megaplasmid contributing to a large genome size. Although less commonly associated with human infection compared to other enterococci, this species can cause disease and persist in diverse niches such as the gut, urinary tract, blood and environment. Few complete genome assemblies have been published to date for .

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Unlabelled: is the leading Gram-positive bacterial species implicated in urinary tract infection (UTI). An opportunistic pathogen, is a commensal of the human gastrointestinal tract (GIT) and its presence in the GIT is a predisposing factor for UTI. The mechanisms by which colonizes and survives in the urinary tract (UT) are poorly understood, especially in uncomplicated or recurrent UTI.

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Vancomycin-resistant E. faecium (VREfm) is a significant public health concern because of limited treatment options. Genomic surveillance can be used to monitor VREfm transmission and evolution.

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Postmenopausal women are severely affected by recurrent urinary tract infection (rUTI). The urogenital microbiome is a key component of the urinary environment. However, changes in the urogenital microbiome underlying rUTI susceptibility are unknown.

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Lactobacillus gasseri frequently colonizes the lower urinary tract of healthy women. However, the role of L. gasseri in urinary tract health and the genes required for urinary tract colonization are poorly understood.

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Lactobacillus crispatus frequently colonizes the vagina and bladder of healthy women. Although its association with vaginal health is relatively well understood, little is known about its role in urinary tract infection (UTI). Here, we report the complete genome sequences of three urinary L.

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Complete genome sequences provide valuable data for the understanding of genetic diversity and unique colonization factors of urinary microbes. These data may include mobile genetic elements, such as plasmids and extrachromosomal phage, that contribute to the dissemination of antimicrobial resistance and further complicate treatment of urinary tract infection (UTI). In addition to providing fine resolution of genome structure, complete, closed genomes allow for the detailed comparative genomics and evolutionary analyses.

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Urinary tract infection (UTI) is one of the most common adult bacterial infections and exhibits high recurrence rates, especially in postmenopausal women. Studies in mouse models suggest that cyclooxygenase-2 (COX-2)-mediated inflammation sensitizes the bladder to recurrent UTI (rUTI). However, COX-2-mediated inflammation has not been robustly studied in human rUTI.

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Recurrent urinary tract infection (rUTI) poses a major health issue, especially among postmenopausal women. We report complete genome sequences of three strains isolated from the urine of postmenopausal women with rUTI. is a recently identified species with clinical and virulence characteristics distinct from those of .

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Uropathogenic (UPEC) is the most common cause of urinary tract infection (UTI). This disease disproportionately affects women and frequently develops into recurrent UTI (rUTI) in postmenopausal women. Here, we report the complete genome sequences of seven UPEC isolates obtained from the urine of postmenopausal women with rUTI.

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