Publications by authors named "Bellastrid Doran"
Article Synopsis
- Staufen1 (STAU1) is a protein that helps control how mRNAs (messenger RNAs) are used in cells and is found in places called mitotic spindles during cell division.
- Researchers found that STAU1 works with ribosomes (the parts that make proteins) while attached to the spindle and that a small part of STAU1 is important for this attachment.
- When STAU1 is removed from cells, important mRNAs and a type of RNA called pre-rRNA get pushed out of place, showing that STAU1 helps move these RNAs to the spindle during cell division and might help keep them stable.
Cell cycle is a highly regulated process that is finely coordinated by a plethora of interconnected regulators. In this paper, we report that post-transcriptional mechanisms mediated by the RNA-binding protein Staufen1 (STAU1) are essential for the proliferation of non-transformed cells (hTERT-RPE1 and IMR90). Cell sorting quantification and time-lapse video microscopy using FUCCI-hTERT-RPE1 cells identified the G/S and G/M phase transitions of the cell cycle as crucial steps for STAU1 functions.
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