Fungal Planet description sheets: 1478-1549.

Novel species of fungi described in this study include those from various countries as follows: , on whitefly, on bark of , from soil under , on leaf spot of , and on leaf spot of . , on fully submersed siliceous schist in high-mountain streams, and on the lower part and apothecial discs of on a twig. , on decaying wood, from moist soil with leaf litter, on a trunk of a living unknown hardwood tree species, and on dead twigs of unidentified plant.

Features of colorectal adenomas among young patients with Lynch syndrome according to path_MMR: Results from the PRED-IdF registry.

Background: Lynch syndrome (LS) is the most frequent inherited colorectal cancer syndrome.

Aim: To assess the burden of adenoma in LS patients under 50 years-old followed in the PRED-IdF network.

Methods: From January 2010 to January 2019, all patients under 50 years of age with a confirmed LS germline mutation were included.

New Insights into Alpine (Basidiomycota): Three New Species, Two Type Revisions, and a New Record for the Alpine Zone.

Thirty-one alpine species of (Agaricales, Cortinariaceae) were described from the alpine zone of the Alps during the second half of the XX century, by the Swiss mycologist Jules Favre, and by the French mycologists Denise Lamoure and Marcel Bon. Notoriously difficult to identify by macro- and microscopical characters, most of these species, which belong to subgen. have been thoroughly revised in global publications based on type sequencing.

Ominoxanthone-The First Xanthone Linearly Fused to a γ-Lactone from Bidaud Basidiomata. CASE- and DFT-Based Structure Elucidation.

The UHPLC-HRMS analysis of basidiomata extract revealed that this mushroom accumulated elevated yields of an unreported specialized metabolite. The molecular formula of this unknown compound, CHO, indicated that a challenging structure elucidation lay ahead, owing to its critically low H/C atom ratio. The structure of this new isolate, namely ominoxanthone (), could not be solved from the interpretation of the usual set of 1D/2D NMR data that conveyed too limited information to afford a single, unambiguous structure.

Fungal Planet description sheets: 1383-1435.

Novel species of fungi described in this study include those from various countries as follows: , , and on soil, from stem cankers of , from stem of , and from leaves of , as endophyte from roots of , from stem of , from leaves of × and from roots of , from intertidal wood and (incl. gen. nov.

Section Species in the Mediterranean Basin: Destroying Angels Reviewed.

In Europe, amatoxin-containing mushrooms are responsible for most of the deadly poisonings caused by macrofungi. The present work presents a multidisciplinary revision of the European species of sect. based on morphology, phylogeny, epidemiology, and biochemistry of amatoxins and phallotoxins.

Fungal diversity notes 1512-1610: taxonomic and phylogenetic contributions on genera and species of fungal taxa.

This article is the 14th in the Fungal Diversity Notes series, wherein we report 98 taxa distributed in two phyla, seven classes, 26 orders and 50 families which are described and illustrated. Taxa in this study were collected from Australia, Brazil, Burkina Faso, Chile, China, Cyprus, Egypt, France, French Guiana, India, Indonesia, Italy, Laos, Mexico, Russia, Sri Lanka, Thailand, and Vietnam. There are 59 new taxa, 39 new hosts and new geographical distributions with one new combination.

Fungal Planet description sheets: 1284-1382.

Novel species of fungi described in this study include those from various countries as follows: , from coastal sea sand. , on soil, on dead wood, from roots and leaves of and from capsules of , (incl. gen.

subgenus in Europe: expanded Sanger and Next Generation Sequencing unveil unexpected diversity in the Mediterranean.

Molecular phylogenies in the past decade have demonstrated that the described diversity of is still underestimated, especially outside continental and boreal ecoregions where the genus has been historically investigated. We tackled this issue by revisiting the so far unresolved subgenus , and focused on the largely unexplored Mediterranean hotspot of biodiversity. The sequencing and phylogenetic analysis of 161 vouchered collections from Austria, Cyprus, France, Germany, Italy and Spain, including 16 types, allowed for the delineation of 11 species in this lineage, three of them recognised as new to science and formally introduced as , and spp.

sect. : new boundaries, extended biogeography and unexpected diversity unravelled by transatlantic studies.

As currently delineated, sect. is a polyphyletic assembly within subg. , encompassing glutinous and pigmented taxa.

Extended phylogeography of the ancestral supports preglacial presence in Europe and Mediterranean origin of morels.

Over 80 species are recognized in the commercially important genus , many of them endemic to specific regions or continents. Among them, and are the earliest diverging lineages and are key in decoding the evolutionary history, global biogeography, and ecological trends within this iconic genus. Early ancestral area reconstruction (AAR) tests postulated a western North American origin of morels but had not included in the analyses , whose phylogenetic identity remained at the time unresolved.

Wavy nature of collagen fibrils deduced from the dispersion of their second-order nonlinear optical anisotropy parameters ρ.

From P-SHG experiments, second-order nonlinear optical anisotropy parameters ρ = χ/χ of collagen tissues are calculated assuming the same model of supercoiled collagen fibril characterized by a variable angle θ. Dispersion of experimental ρ values is converted into distribution of θ values based on the wavy nature of collagen fibrils deduced from EM studies. For tendon, the results show that the dispersion of experimental ρ values is mainly due to Poisson photonic shot noise assuming a slight fibrillar undulation with θ = 2.

Fungal Planet description sheets: 868-950.

Novel species of fungi described in this study include those from various countries as follows: , and on leaves, , and on leaves, and on leaves, on leaves, on litter of regenerating subtropical rainforest, (incl. gen. nov.

Back-to-Back Comparison of Colonoscopy With Virtual Chromoendoscopy Using a Third-Generation Narrow-Band Imaging System to Chromoendoscopy With Indigo Carmine in Patients With Lynch Syndrome.

Introduction: Colonoscopic screening with indigo carmine chromoendoscopy (ICC) in patients with Lynch syndrome (LS) improves the adenoma detection rate but is time consuming and poorly used in clinical practice. Narrow-band imaging (NBI), a virtual chromoendoscopy technique, highlights superficial mucosal vessels and improves adenoma characterization. We conducted a prospective multicenter trial in a back-to-back fashion to compare the third-generation NBI with ICC for detecting colonic adenomas in patients with LS.

Phylogenetic and distributional data on boletoid fungi (Boletaceae) in Cyprus and description of a new sampling methodology.

The data presented here was obtained during a decade-long macromycete inventory on the island of Cyprus and is supplementary to the research article "Present status and future of boletoid fungi () on the island of Cyprus: cryptic and threatened diversity unravelled by ten-year study" [1]. A new, rainfall-based sampling protocol for documenting fungal diversity in Mediterranean ecosystems, is described in detail.

Diversity of (, ) in Europe, and typification of .

In this study, eight species of are recognized from Europe: , aff. 1, , cf, , . cf.

Fungal Planet description sheets: 951-1041.

Novel species of fungi described in this study include those from various countries as follows: , from permafrost, from an unidentified marine sponge. , on humus in mixed forest. , Golovinomyces glandulariae on on leaves of on leaves of on leaves of , on soil, on rotten stalks of on leaf litter covered soil, (incl.

Fungal Planet description sheets: 716-784.

Novel species of fungi described in this study include those from various countries as follows: , on leaf litter, from × hybrid, on subsp. on on on sp., on sp.

Clinical implications of CTNNA1 germline mutations in asymptomatic carriers.

In 2017, we implemented CTNNA1 germline analysis in probands suspected of having hereditary diffuse gastric cancer. Here, we report the results from a retrospective series of 41 cases, including the identification of a new family with a CTNNA1 mutation and the first prophylactic total gastrectomy in an asymptomatic carrier after a normal upper endoscopy. Diffuse gastric cancer foci with loss of catenin alpha-1 expression were seen in the resected tissue, suggesting that CTNNA1 and CDH1 germline mutations behave in a similar manner.

section and section (, ), a morphogenetic overview of European and North American species.

is the largest genus of ectomycorrhizal fungi worldwide. Recent molecular studies have shown high levels of morphological homoplasy within the genus. Importantly, DNA phylogenies can reveal characteristics that have been either over- or underemphasized in taxonomic studies.

The genus (): a ribosomal DNA-based phylogeny and revised systematics of European 'deer truffles'.

('deer truffles') is one of the most important ectomycorrhizal fungal genera in temperate and subarctic forest ecosystems, but also one of the least documented in public databases. The current systematics are mainly based on macromorphology, and is not significantly different from that proposed by Vittadini (1831). Within the 49 species recognised worldwide, 23 were originally described from Europe and 17 of these were described before the 20th century.

Surveillance of Duodenal Polyposis in Familial Adenomatous Polyposis: Should the Spigelman Score Be Modified?

Background: Duodenal polyposis is a manifestation of adenomatous polyposis that predisposes to duodenal or ampullary adenocarcinoma. Duodenal polyposis is monitored by upper GI endoscopies and may require iterative resections and prophylactic radical surgical treatment when malignancy is threatening.

Objective: The purpose of this study was to evaluate severity scoring for surveillance and treatment in a large series of duodenal polyposis.

Determination of extracellular matrix collagen fibril architectures and pathological remodeling by polarization dependent second harmonic microscopy.

Polarization dependence second harmonic generation (P-SHG) microscopy is gaining increase popularity for in situ quantification of fibrillar protein architectures. In this report, we combine P-SHG microscopy, new linear least square (LLS) fitting and modeling to determine and convert the complex second-order non-linear optical anisotropy parameter ρ of several collagen rich tissues into a simple geometric organization of collagen fibrils. Modeling integrates a priori knowledge of polyhelical organization of collagen molecule polymers forming fibrils and bundles of fibrils as well as Poisson photonic shot noise of the detection system.