Promoting Diversity in the Biomedical Sciences with the Teen Science Ambassador Program.

Mental health and substance use fields suffer from underrepresentation of racially and ethnically minoritized, first-generation college student, and female members. The homogeny of the current workforce can impede scientific productivity, creativity, and problem-solving in addressing health-related issues. Our team developed the Teen Science Ambassador Program (TSAP) to provide underrepresented minoritized (URM) high school students with science-focused education, research opportunities, and mentoring within their community.

Public perceptions of climate tipping points.

Coverage of climate tipping points has rapidly increased over the past 20 years. Despite this upsurge, there has been precious little research into how the public perceives these abrupt and/or irreversible large-scale risks. This article provides a nationally representative view on public perceptions of climate tipping points and possible societal responses to them ( = 1773).

Barriers and facilitators to primary care research: views of GP trainees and trainers.

Background: Primary care plays an important role in the conception and delivery of transformational research but GP engagement is lacking, prompting calls for the promotion of academic opportunities in primary care.

Aim: To identify potential barriers and facilitators among GP trainees and trainers in primary care research to inform support given by Local Clinical Research Networks (LCRNs).

Design & Setting: A cross-sectional online survey was developed and distributed by the CRN to GP trainees and trainers in the North East and North West.

The effect of ambient sounds on decision-making and heart rate variability in autism.

Many autistic people report difficulties making decisions during everyday tasks, such as shopping. To examine the effect of sounds on decision-making, we developed a supermarket task where people watched a film shown from the shopper's perspective and were asked to make decisions between different products. The task was divided into three sections and participants completed each section in a different auditory environment: (1) no sounds, (2) non-social sounds (e.

Prevalence Rates of Sexual Behaviors, Condom Use, and Contraception Among Australian Heterosexual Adolescents.

Background: The development of effective health promotion practices and education programs to reduce rates of sexually transmitted infections and unintended pregnancy requires accurate, up-to-date information about young people's sexual behaviors.

Aims: To provide prevalence rates on sexual behaviors and condom and contraceptive use for Australian year 10-12 heterosexual students in a nationally representative sample.

Methods: A nationally representative sample of 2,301 male and 2,055 female year 10 through 12 heterosexual students were recruited to an online survey about their lifetime sexual behaviors and condom and contraceptive use.

'It's kinda bad, honestly': Australian students' experiences of relationships and sexuality education.

Relationships and sexuality education for young people in Australia and elsewhere is a controversial topic. Numerous studies in Australia have focused on curriculum, policy, teachers, schools, sexting and other behaviours, and knowledge regarding sexually transmitted infection (STI)/human immunodeficiency virus (HIV) and pregnancy prevention. Few large-scale national studies have engaged with young people about what they want out of their sex education, and what they suggest would be most valuable for future programs in Australia.

Study Protocol: 6th National Survey of Australian Secondary Students and Adolescent Sexual Health, 2018.

Since 1992 the Australian Government has funded a periodic national survey of HIV and Sexually Transmissible Infection (STI) knowledge and sexual risk behavior among secondary school students. Adolescents continue to be a priority population in public health efforts to reduce rates of STIs in Australia. The purpose of the survey is to inform progress on national strategic sexual health priorities.

Perceptions of bioenergy with carbon capture and storage in different policy scenarios.

There is growing interest in bioenergy with carbon capture and storage (BECCS) as a possible technology for removing CO from the atmosphere. In the first study of its kind, we investigate whether and how different forms of incentivisation impact on public perceptions of this technology. We develop a new experimental method to triangulate perceptions of BECCS in different policy scenarios through quantitative measurement and qualitative elicitation.

Outpatient parenteral antimicrobial therapy.

Outpatient parenteral antibiotic therapy enables patients to receive intravenous antibiotics without having to be an inpatient. Outpatient parenteral antibiotic therapy can be delivered in an outpatient setting or in the patient's own home by a visiting nurse or the patient can be trained to self-administer antibiotic treatment. The advantages and limitations of each of these methods are discussed in this article.

A Sociotechnical Framework for Governing Climate Engineering.

Proposed ways of governing climate engineering have most often been supported by narrowly framed and unreflexive appraisals and processes. This article explores the governance implications of a Deliberative Mapping project that, unlike other governance principles, have emerged from an extensive process of reflection and reflexivity. In turn, the project has made significant advances in addressing the current deficit of responsibly defined criteria for shaping governance propositions.

Political legitimacy and European monetary union: contracts, constitutionalism and the normative logic of two-level games.

The crisis of the euro area has severely tested the political authority of the European Union (EU). The crisis raises questions of normative legitimacy both because the EU is a normative order and because the construction of economic and monetary union (EMU) rested upon a theory that stressed the normative value of the depoliticization of money. However, this theory neglected the normative logic of the two-level game implicit in EMU.

Crafting a public for geoengineering.

In a short period of time, climate 'geoengineering' has been added to the list of technoscientific issues subject to deliberative public engagement. Here, we analyse this rapid trajectory of publicization and explore the particular manner in which the possibility of intentionally altering the Earth's climate system to curb global warming has been incorporated into the field of 'public engagement with science'. We describe the initial framing of geoengineering as a singular object of debate and subsequent attempts to 'unframe' the issue by placing it within broader discursive fields.

Novel respiratory viruses: what should the clinician be alert for?

Since 1990, several novel respiratory viruses affecting humans have been described. In this review, we focus on three pathogens that have caused significant human mortality and raise important public health concerns: severe acute respiratory syndrome (SARS)-coronavirus, Middle East respiratory syndrome (MERS)-coronavirus and avian influenza A viruses (H5N1 and H7N9). Novel respiratory viruses have the potential to instil fear in the public and physicians alike if they are associated with a high case fatality rate.

Deliberative Mapping of options for tackling climate change: Citizens and specialists 'open up' appraisal of geoengineering.

Appraisals of deliberate, large-scale interventions in the earth's climate system, known collectively as 'geoengineering', have largely taken the form of narrowly framed and exclusive expert analyses that prematurely 'close down' upon particular proposals. Here, we present the findings from the first 'upstream' appraisal of geoengineering to deliberately 'open up' to a broader diversity of framings, knowledges and future pathways. We report on the citizen strand of an innovative analytic-deliberative participatory appraisal process called Deliberative Mapping.

Outpatient parenteral antibiotic therapy in primary hip and knee arthroplasty infection managed with debridement and retention of prosthesis: a retrospective cohort study.

Background: Attempted joint salvage of infected primary arthroplasty traditionally has utilized joint washouts in combination with costly long-term inpatient parenteral antibiotic regimens. Outpatient and home parenteral antibiotic therapy (OHPAT) represents a potential alternative. However, there is a lack of published data on its value for primary deep arthroplasty infection.

Vaccines for preventing anthrax.

Background: Anthrax is a bacterial zoonosis that occasionally causes human disease and is potentially fatal. Anthrax vaccines include a live-attenuated vaccine, an alum-precipitated cell-free filtrate vaccine, and a recombinant protein vaccine.

Objectives: To evaluate the effectiveness, immunogenicity, and safety of vaccines for preventing anthrax.

HIV: treating tuberculosis.

Introduction: In people infected with both HIV and Mycobacterium tuberculosis, the annual risk of developing active tuberculosis is 5% to 10% - more than 10 times the rate for HIV-negative people with M tuberculosis infection. Untreated, mortality from tuberculosis in people with HIV is likely to be high, and over 5% of people relapse after successful treatment.

Methods And Outcomes: We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of first-line treatments for tuberculosis in HIV-positive people? What are the effects of second-line treatments for tuberculosis in HIV-positive people? We searched: Medline, Embase, The Cochrane Library, and other important databases up to July 2009 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review).

Fever of unknown origin.

There are many potential causes of FUO. Most cases are due to unusual presentations of common diseases rather than rare or exotic diseases. The key to establishing the diagnosis is a careful history and careful repeated examinations followed by targeted investigations.

Near-atomic resolution using electron cryomicroscopy and single-particle reconstruction.

Electron cryomicroscopy (cryo-EM) yields images of macromolecular assemblies and their components, from which 3D structures can be determined, by using an image processing method commonly known as "single-particle reconstruction." During the past two decades, this technique has become an important tool for 3D structure determination, but it generally has not been possible to determine atomic models. In principle, individual molecular images contain high-resolution information contaminated by a much higher level of noise.

HIV: treating Pneumocystis pneumonia (PCP).

Introduction: Pneumocystis pneumonia (PCP) is a common AIDS-defining opportunistic illness in people with HIV infection, but its incidence has fallen with use of prophylactic treatment. Without treatment, PCP is likely to be fatal in people with AIDS, so placebo-controlled studies would be considered unethical.

Methods And Outcomes: We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of first-line antipneumocystis treatments for Pneumocystis pneumonia in people infected with HIV? What are the effects of adjuvant corticosteroids in people receiving first-line antipneumocystis treatments for Pneumocystis pneumonia in people infected with HIV? What are the effects of treatments for Pneumocystis pneumonia in people infected with HIV who have not responded to first-line antipneumocystis treatment? We searched: Medline, Embase, The Cochrane Library, and other important databases up to May 2008 (BMJ Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review).

Transparent development of the WHO rapid advice guidelines.

Emerging health problems require rapid advice. We describe the development and pilot testing of a systematic, transparent approach used by the World Health Organization (WHO) to develop rapid advice guidelines in response to requests from member states confronted with uncertainty about the pharmacological management of avian influenza A (H5N1) virus infection. We first searched for systematic reviews of randomized trials of treatment and prevention of seasonal influenza and for non-trial evidence on H5N1 infection, including case reports and animal and in vitro studies.