Publications by authors named "Bellakhal S"
Article Synopsis
- TNF alpha blockers like infliximab (IFX) and adalimumab (ADA) are effective for inflammatory diseases but about 30% of patients don't respond, possibly due to anti-drug antibodies (ADAbs).
- A study involving 197 patients found that 40% of those on IFX and 25% on ADA tested positive for ADAbs, with varying rates across conditions (RA, SpA, and CD).
- Despite the presence of ADAbs being linked to lower drug levels, they did not correlate with disease activity, suggesting that other factors besides immunogenicity may influence treatment failures.
Systemic diseases should be always considered when managing unexplained intestinal pseudo-obstruction. Intestinal pseudo-obstruction related to systemic lupus erythematosus is often responsive to corticosteroid therapy when promptly treated.
View Article and Find Full Text PDFIntroduction: The quality of the training of medical students is one of the guarantors of the proper functioning of our health system. Gamification is an innovative educational pedagogical method that stimulates the pleasure of learning and encourages learner motivation.
Aim: To evaluate the subjective and external motivations and academic self-efficacy of DCEM1 students by playing with TD sessions designed to learn the systematic interpretation of rhythm disorders on surface ECGs using playing cards.
Background: Iron deficiency is the most common nutritional deficiency worldwide and its resulting anemia appears as a public health problem. Iron deficiency anemia is rather a symptom than a disease in itself, and the identification of its etiology is of paramount importance.
Aim: to study the clinical and etiological features of iron deficiency anemia in an Internal Medicine department.
Background: Stiff Person Syndrome (SPS) is a rare autoimmune neurological disorder which is often misdiagnosed. We report here a case of SPS with a long diagnosis delay.
Case: A 36-year-old man presented with an 11-year history of progressive stiffness and painful spasms of his both legs, with recent worsening of his condition over the last year resulting in a considerable difficulty of standing up and walking.
Background: Infiximab has been shown to be effective in inducing and maintaining remission of intestinal bowel diseases. Infiximab has been associated with many adverse events. Articular manifestations are commonly reported, but they are of variable clinical expression and aetiology.
View Article and Find Full Text PDFObjective: To describe safety and efficacy of rituximab in patients with systemic sclerosis.
Methods: We included 13 patients with systemic sclerosis treated with rituximab and pooled with 40 additional patients from the literature. SSc rituximab untreated patients were matched to rituximab treated ones.
[Systemic lupus erythematosus presenting as Stevens-Johnson syndrome].
Pathol Biol (Paris)
September 2015
Stevens-Johnson syndrome and toxic epidermal necrolysis are life-threatening dermatological conditions. Their most common cause is medication. However, in a small proportion of patients these dermatological conditions could be the first presentation of systemic lupus erythematosus.
View Article and Find Full Text PDFBackground: Behçet's disease is a multisystemic inflammatory disease characterized by recurrent oral and genital ulcers, skin lesions and uveitis. The diagnosis of Behçet's disease is based on clinical criteria. The etiology of the disease is unknown but the wide variations of ethnic prevalence and of the prevalence in the same ethnic group in different geographic areas indicate environmental triggering of a genetically determined disorder.
View Article and Find Full Text PDFObjective: To study the maternal and fetal outcomes in women with systemic lupus erythematosus.
Patients And Methods: A retrospective study of 26 pregnancies in 15 systemic erythematosus patients diagnosed before or during pregnancy regarding to American College of Rheumatology criteria in a single reference center.
Results: The mean patient age was 31.
Objective: The aim of the present study was to analyze demographic, clinical and genetic features of Behçet's disease patients with neurological involvement through a monocentric study of a homogenous group of hospitalized patients observed in the same department and to compare them with those of other ethnic and geographic groups.
Methods: Four hundred and thirty Behçet's disease (BD) patients were retrospectively studied. Diagnosis of BD was made according to the international study group for Behçet's disease criteria.