Background: The antiproliferative and apoptotic effects of ellagic acid, a dietary polyphenol, were studied.
Materials And Methods: The neutral red cytotoxicity assay compared the sensitivities of gingival fibroblasts and HSC-2 oral carcinoma cells to ellagic acid. The ferrous ion oxidation xylenol orange assay and levels of intracellular reduced glutathione were used to assess pro-oxidant nature of ellagic acid.